Center for Global Health, Weill Cornell Medicine, New York, NY, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
J Clin Hypertens (Greenwich). 2021 Jul;23(7):1452-1456. doi: 10.1111/jch.14300. Epub 2021 Jun 2.
People with HIV (PWH) have a >2-fold greater risk for development of cardiovascular disease (CVD), which may be associated with abnormalities in 24-h ambulatory blood pressure measurement (ABPM) profile. We conducted a nested case-control study of ABPM in 137 PWH and HIV-uninfected controls with normal and high clinic blood pressure (BP) in Tanzania. Nocturnal non-dipping of heart rate (HR) was significantly more common among PWH than HIV-uninfected controls (p = .01). Nocturnal non-dipping of BP was significantly more common in PWH with normal clinic BP (p = .048). Clinical correlates of nocturnal non-dipping were similar in PWH and HIV-uninfected adults and included higher BMI, higher CD4 cell count, and high C-reactive protein for HR and markers of renal disease for BP. In conclusion, nocturnal non-dipping of both BP and HR was more common in PWH but further research is needed to determine causes and consequences of this difference.
HIV 感染者（PWH）发生心血管疾病（CVD）的风险增加了 2 倍以上，这可能与 24 小时动态血压测量（ABPM）结果异常有关。我们在坦桑尼亚开展了一项嵌套病例对照研究，纳入了 137 名 HIV 感染者和 HIV 未感染者，这些参与者的诊室血压正常或偏高。与 HIV 未感染者相比，PWH 中夜间心率（HR）非杓型的比例显著更高（p =.01）。夜间血压非杓型在诊室血压正常的 PWH 中更为常见（p =.048）。夜间 HR 非杓型和夜间 BP 非杓型的临床相关性在 PWH 和 HIV 未感染者中相似，包括更高的 BMI、更高的 CD4 细胞计数、更高的 C 反应蛋白与 HR 相关，以及与 BP 相关的肾脏疾病标志物。总之，夜间 HR 和 BP 非杓型在 PWH 中更为常见，但仍需要进一步研究以确定这种差异的原因和后果。
