Center for Precision Medicine Multi-Omics Research, Peking University Health Science Center, Peking University, Beijing 100191, China.
School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
J Proteome Res. 2021 Jul 2;20(7):3463-3474. doi: 10.1021/acs.jproteome.1c00054. Epub 2021 Jun 3.
The COVID-19 pandemic has become a worldwide health crisis. So far, most studies have focused on the epidemiology and pathogenesis of this infectious disease. Little attention has been given to the disease sequelae in patients recovering from COVID-19, and nothing is known about the mechanisms underlying these sequelae. Herein, we profiled the serum proteome of a cohort of COVID-19 patients in the disease onset and recovery stages. Based on the close integration of our proteomic analysis with clinical data, we propose that COVID-19 is associated with prolonged disorders in cholesterol metabolism and myocardium, even in the recovery stage. We identify potential biomarkers for these disorders. Moreover, severely affected patients presented more serious disturbances in these pathways. Our findings potentially support clinical decision-making to improve the prognosis and treatment of patients.
COVID-19 大流行已成为全球卫生危机。到目前为止，大多数研究都集中在这种传染病的流行病学和发病机制上。对于从 COVID-19 中康复的患者的疾病后遗症，人们关注甚少，而对于这些后遗症的潜在机制也一无所知。在此，我们对一组 COVID-19 患者在发病和恢复期的血清蛋白质组进行了分析。通过将我们的蛋白质组学分析与临床数据紧密结合，我们提出 COVID-19 与胆固醇代谢和心肌紊乱有关，甚至在恢复期也是如此。我们确定了这些紊乱的潜在生物标志物。此外，受严重影响的患者在这些途径中表现出更严重的紊乱。我们的研究结果可能为改善患者预后和治疗的临床决策提供支持。
