College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.
Affiliated Hospital of Yanbian University, Yanji, Jilin, China.
J Enzyme Inhib Med Chem. 2021 Dec;36(1):1165-1197. doi: 10.1080/14756366.2021.1931861.
Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications. Over 100 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antioxidant, and other activities, were reviewed. This article reviewed investigations regarding piperazine groups for the modification of natural product derivatives in the last decade, highlighting parameters that affect their biological activity.
哌嗪部分是一种含有两个氮原子在 1 位和 4 位以及四个碳原子的环状分子。哌嗪是开发具有广泛应用的新型候选药物的最受欢迎的杂环之一。综述了 100 多种具有广泛生物活性的分子，包括抗肿瘤、抗菌、抗炎、抗氧化等活性。本文综述了过去十年中哌嗪基团对天然产物衍生物修饰的研究，强调了影响其生物活性的参数。
