Wang Xiyue, Hu Qingyun, Tang Hui, Pan Xinhui
Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmaceutical Sciences, Shihezi University, Shihezi 832002, China.
Pharmaceuticals (Basel). 2023 Feb 2;16(2):228. doi: 10.3390/ph16020228.
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.
异恶唑和异恶唑啉是含有氮和氧的五元杂环分子。异恶唑和异恶唑啉是开发新型候选药物最常用的杂环化合物。本文综述了80多种具有广泛生物活性的分子，包括抗肿瘤、抗菌、抗炎、抗糖尿病、心血管等活性。本文介绍了对异恶唑和异恶唑啉部分衍生物活性在天然产物中应用的最新研究综述，重点关注影响这些化合物生物活性的参数。
