Consultant Paediatric Otolaryngologist, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Consultant in Otolaryngology/Head & Neck Surgery, Aintree University Hospital, Liverpool, UK.
Expert Opin Pharmacother. 2021 Oct;22(14):1901-1908. doi: 10.1080/14656566.2021.1935870. Epub 2021 Jul 5.
: Recurrent respiratory papillomatosis is a rare human papillomavirus (HPV)-induced condition where warts grow within the airway and especially the larynx to effect voice and restrict breathing.: A PubMed search using the following search terms was performed: respiratory papillomatosis and cidofovir, alpha-interferon, bevacizumab, PD1, and HPV vaccines. Surgery remains the mainstay of treatment. There has been a change in options available for adjuvant therapies with systemic bevacizumab and the potential benefits of prophylactic HPV vaccine. Despite efforts to identify a drug therapy to control RRP, no therapy yet remains which is predictable and effective in all. The current status of therapeutic vaccines and immunotherapy is discussed.: The current adjuvant therapies do offer a reasonable expectation of control but the effect for the individual is unpredictable despite the therapies being based on good science. The current therapies would allow an escalating treatment strategy to be formulated, however a single therapy is unlikely to be curative. Multi-center trials are required such that adequate numbers to show an effect are achieved.
复发性呼吸道乳头瘤病是一种罕见的人乳头瘤病毒（HPV）引起的疾病，疣在气道内，特别是在喉部生长，影响声音并限制呼吸。使用以下搜索词在 PubMed 上进行了搜索：呼吸道乳头瘤病和西多福韦、α干扰素、贝伐珠单抗、PD1 和 HPV 疫苗。手术仍然是治疗的主要方法。随着全身性贝伐珠单抗和预防性 HPV 疫苗的潜在益处，辅助治疗的选择发生了变化。尽管人们努力寻找一种药物治疗来控制 RRP，但目前还没有一种治疗方法在所有方面都是可预测和有效的。讨论了治疗性疫苗和免疫疗法的现状。目前的辅助治疗确实提供了合理的控制预期，但尽管这些治疗方法基于良好的科学，但对个体的效果是不可预测的。目前的治疗方法可以制定出一种递增的治疗策略，但单一的治疗方法不太可能治愈。需要进行多中心试验，以便获得足够的数量来显示效果。
