28730All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Int J Surg Pathol. 2022 Feb;30(1):106-113. doi: 10.1177/10668969211022017. Epub 2021 Jun 3.
Phyllodes tumor is a paradigm of fibroepithelial neoplasm that accounts for <1% of the breast neoplastic lesions usually detected in females and uncommonly in the male breast. The World Health Organization classifies the tumor into benign, borderline, and malignant based on the predefined morphological criteria. Squamous differentiation in phyllodes tumor is epithelial metaplasia, which has been occasionally documented in English literature. We report the first undocumented case of a recurrent borderline phyllodes tumor with cystic squamous metaplastic change in a 32-year-old male patient. The histology was that of a fibroepithelial neoplasm with the typical leaf-like projections and cystic spaces lined by squamous epithelium containing keratin debris. The purpose of presenting this case is to elucidate the pathogenesis and discuss other malignant and benign breast lesions that may be included in the differential diagnosis when evaluating a breast lesion with squamous metaplasia, particularly in the context of fine-needle aspirates.
叶状肿瘤是一种纤维上皮性肿瘤，占女性乳腺肿瘤的<1%，男性乳腺中较为罕见。世界卫生组织（WHO）根据预先设定的形态学标准，将肿瘤分为良性、交界性和恶性。叶状肿瘤中的鳞状分化是上皮化生，这在英文文献中偶尔有记载。我们报告首例未被记录的复发性交界性叶状肿瘤，伴有囊性鳞状化生，发生于 32 岁男性患者。组织学表现为具有典型叶状突起的纤维上皮性肿瘤，伴囊性空间，由鳞状上皮衬里，含有角蛋白碎片。提出该病例的目的是阐明其发病机制，并讨论在评估具有鳞状化生的乳腺病变时，特别是在细针抽吸的情况下，可能包含在鉴别诊断中的其他良性和恶性乳腺病变。
