Department of Interventional Therapy, Department of Radiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, Jiangsu, PR China.
College of Medical Imaging, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, PR China.
Acta Biomater. 2021 Aug;130:374-384. doi: 10.1016/j.actbio.2021.05.031. Epub 2021 May 31.
Transcatheter arterial chemoembolization (TACE) is the main treatment for liver cancer. Although many embolic agents have been exploited in TACE, embolic agents combining embolization, drug loading, and imaging properties have not yet been constructed. Herein, we report a new magnetic mesoporous embolic microsphere that can simultaneously be loaded with doxorubicin (Dox), block vessels, and be observed by magnetic resonance imaging (MRI). The microspheres were prepared by decorating magnetic polystyrene/FeO particles with mesoporous organosilica microparticles (denoted as PS/FeO@MONs). The PS/FeO@MONs were uniformly spherical and large (50 µm), with a high specific surface area, uniform mesopores, and a Dox loading capacity of 460.8 µg mg. Dox-loaded PS/FeO@MONs (PS/FeO@MON@Dox) effectively inhibited liver cancer cell growth. A VX2 rabbit liver tumor model was constructed to study the efficacy of TACE with PS/FeO@MON@Dox. In vivo, PS/FeO@MON@Dox could be smoothly delivered through an arterial catheter to achieve chemoembolization. Moreover, PS/FeO@MON@Dox and residual tumor parenchyma could be distinguished on MRI, which is of great significance for evaluating the efficacy of TACE. Histopathology showed that PS/FeO@MON@Dox could be deposited in the tumor vessels, completely blocking the blood supply. Overall, PS/FeO@MON@Dox showed good drug loading, embolization and imaging performance as well as potential for use in TACE. STATEMENT OF SIGNIFICANCE: Transcatheter arterial chemoembolization (TACE) is the main treatment for liver cancer. Although many embolic agents have been exploited in TACE, embolic agents combining embolization, drug-loading, and imaging properties have not yet been constructed. In this work, we prepared magnetic mesoporous microspheres as a new embolic agent that can simultaneously load doxorubicin (Dox), block blood vessels and enable magnetic resonance imaging. Overall, this new embolic microsphere-mediated TACE strategy for liver cancer showed good therapeutic effects, and the PS/FeO@MON@Dox embolic microspheres provide a new avenue for improving the efficacy of TACE for liver cancer and postoperative evaluation.
经导管动脉化疗栓塞术（TACE）是肝癌的主要治疗方法。虽然 TACE 中已经开发了许多栓塞剂，但尚未构建具有栓塞、药物负载和成像特性相结合的栓塞剂。在此，我们报告了一种新的磁性介孔栓塞微球，它可以同时负载多柔比星（Dox）、阻断血管并通过磁共振成像（MRI）观察。该微球是通过用介孔有机硅微球（表示为 PS/FeO@MONs）修饰磁性聚苯乙烯/FeO 颗粒制备的。PS/FeO@MONs 呈均匀球形且较大（50 µm），具有高比表面积、均匀的介孔和 460.8 µg mg 的 Dox 载药量。负载 Dox 的 PS/FeO@MONs（PS/FeO@MON@Dox）有效抑制肝癌细胞生长。构建 VX2 兔肝癌模型研究 PS/FeO@MON@Dox 的 TACE 疗效。在体内，PS/FeO@MON@Dox 可通过动脉导管顺利输送以实现化疗栓塞。此外，PS/FeO@MON@Dox 和残留肿瘤实质可在 MRI 上区分，这对于评估 TACE 的疗效具有重要意义。组织病理学显示 PS/FeO@MON@Dox 可沉积在肿瘤血管中，完全阻断血液供应。总体而言，PS/FeO@MON@Dox 表现出良好的载药、栓塞和成像性能，具有用于 TACE 的潜力。
经导管动脉化疗栓塞术（TACE）是肝癌的主要治疗方法。虽然 TACE 中已经开发了许多栓塞剂，但尚未构建具有栓塞、药物加载和成像性能相结合的栓塞剂。在这项工作中，我们制备了磁性介孔微球作为一种新的栓塞剂，它可以同时负载多柔比星（Dox）、阻断血管并进行磁共振成像。总体而言，这种新的栓塞微球介导的肝癌 TACE 策略显示出良好的治疗效果，PS/FeO@MON@Dox 栓塞微球为提高肝癌 TACE 疗效和术后评估提供了新途径。
