Department of Medical Physics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Interventional Radiotherapy Ward, Department of Radiation Oncology, Jundishapur University of Medical Sciences, Ahvaz, Iran.
Appl Radiat Isot. 2021 Aug;174:109776. doi: 10.1016/j.apradiso.2021.109776. Epub 2021 May 13.
Therapeutic advantages of Grid therapy have been demonstrated in several theoretical studies using the standard linear-quadratic (LQ) model. However, the suitability of the LQ model when describing cell killing at highly modulated radiation fields has been questioned. In this study, we have applied an extended LQ model to recalculate therapeutic parameters of Grid therapy. This study shows that incorporating the bystander effects in the radiobiological models would significantly change the theoretical predictions and conclusion of Grid therapy, especially at high dose gradient fields.
Grid 疗法的治疗优势已在使用标准线性二次（LQ）模型的多项理论研究中得到证实。然而，LQ 模型在描述高度调制辐射场中的细胞杀伤时的适用性受到了质疑。在这项研究中，我们应用了扩展的 LQ 模型来重新计算 Grid 疗法的治疗参数。研究表明，将旁观者效应纳入放射生物学模型将显著改变 Grid 疗法的理论预测和结论，特别是在高剂量梯度场中。
