Montagna W, Carlisle K, Brenner R M
Oregon Regional Primate Research Center, Beaverton 97006.
Arch Dermatol Res. 1988;280 Suppl:S68-84.
We studied wound healing in methacrylate- and araldite-embedded sex skin, a unique tissue that embodies the properties of friction surface and hairy skin. The largely light-microscopic observations were supplemented with transmission electron microscopy. The time of epidermal bridging was directly dependent on how closely apposed were the wound margins. Repair in the dermis always occurred more rapidly in the upper and in the lower parts of the wound gap than in the middle. Early in healing, the original epidermis cut off a wedge of skin in the upper wound margin (precocious remodeling) and cast it off at the margin of the clot. Remodeling (collagen resorption) inside the wound gap is accomplished primarily by fibroclasts. All mast cells in the vicinity of the wound attain fatty vacuoles. Adipose tissue near the wound undergoes lipolysis: the adipocytes gradually become smaller and their cytoplasm reticulated as small fat vesicles are extruded in the interstitium; fibroblasts, macrophages, polymorphonuclear leukocytes (PMNs) and mast cells readily phagocytose the fat vesicles. Elastic fibers do not participate in wound healing. There was no evidence of elastic fiber formation in granulation tissue.
我们研究了甲基丙烯酸酯和环氧树脂包埋的性皮肤中的伤口愈合情况，性皮肤是一种独特的组织，兼具摩擦表面和多毛皮肤的特性。主要通过光学显微镜观察，并辅以透射电子显微镜观察。表皮桥接的时间直接取决于伤口边缘的贴合程度。伤口间隙上部和下部的真皮修复总是比中部更快。在愈合早期，原始表皮在上部伤口边缘切下一块楔形皮肤（早熟重塑），并在血凝块边缘将其脱落。伤口间隙内的重塑（胶原吸收）主要由纤维破骨细胞完成。伤口附近的所有肥大细胞都有脂肪空泡。伤口附近的脂肪组织发生脂解作用：脂肪细胞逐渐变小，其细胞质呈网状，因为小脂肪小泡被挤出到间质中；成纤维细胞、巨噬细胞、多形核白细胞（PMN）和肥大细胞很容易吞噬脂肪小泡。弹性纤维不参与伤口愈合。在肉芽组织中没有弹性纤维形成的证据。
