Jeanmougin M, Civatte J
Service de Dermatologie, Hôpital Saint-Louis, Paris, France.
Arch Dermatol Res. 1988;280 Suppl:S90-3.
The predictive phototoxicity test known as photoepidermotest consists of twice daily applications of the product tested for 16 days, followed by total spectrum irradiation with a 2,500-W Xenon lamp in infraerythema and supraerythema doses. Phototoxicity is revealed by an erythema with the infraerythema dose and/or by accentuation of the erythema provoked by the supraerythema dose when compared with the "irradiation only" (i.e., no product) control skin area. This technique, used in a controlled, double-blind trial, showed that a 10% benzoyl peroxide (BPO) gel was phototoxic in eight out of 18 subjects tested (44%). It also showed that adding a UVB filter (phenylbenzimidazole sulfonic acid 1%) to the BPO preparation was effective in preventing phototoxic reactions in seven of these eight subjects.
一种名为光表皮试验的预测性光毒性试验，包括每天两次涂抹受试产品，持续16天，然后用2500瓦氙灯以亚红斑剂量和超红斑剂量进行全光谱照射。与“仅照射”（即不涂抹产品）的对照皮肤区域相比，亚红斑剂量照射出现红斑和/或超红斑剂量照射导致红斑加重，即表明存在光毒性。在一项对照双盲试验中采用该技术，结果显示，在18名受试对象中，有8名（44%）使用10%过氧化苯甲酰（BPO）凝胶出现了光毒性。试验还表明，在这8名受试对象中，有7名在BPO制剂中添加紫外线B滤光剂（1%苯基苯并咪唑磺酸）后有效预防了光毒性反应。
