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注射用冷冻凝胶联合脂肪来源干细胞治疗急性心肌梗死后的心脏修复。

Injectable Cryogels Associate with Adipose-Derived Stem Cells for Cardiac Healing After Acute Myocardial Infarctions.

机构信息

Department of Cardiovascular Surgery, People's Liberation Army General Hospital, Beijing 100853, China.

出版信息

J Biomed Nanotechnol. 2021 May 1;17(5):981-988. doi: 10.1166/jbn.2021.3082.

Abstract

Treatment of adipose-derived stem cells (ADSCs) provides support for novel methods of conveying baseline cell protein endothelial cells to promote acute myocardial infarction in gelatin sericin (GS) lamin-coated antioxidant systems (GS@L). The ratio of fixity modules, pores, absorption, and inflammation in the range of ka (65 ka), 149 ±39.8 μm, 92.2%, 42 ± 1.38, and 29 ± 1.9 were observed in the synthesized frames for GS. Herein, ADSC-GS@L was prepared, and the relevant substance for the development of cardiac regenerative applications was stable and physically chemical. assessments of ADSC-GS@L injectable cryogels established the enhanced survival rates of the cell and improved pro- angiogenic factors as well as pro-inflammatory expression, confirming the favorable outcomes of fractional ejections, fibro-areas, and vessel densities with reduced infraction dimensions. The novel ADSC-injecting cryogel method could be useful for successful heart injury therapies during acute myocardial infarction. Additionally, the method could be useful for successful heart injury therapies during coronary heart disease.

摘要

脂肪来源的干细胞(ADSCs)的治疗为传递基础细胞蛋白内皮细胞提供了支持,以促进明胶丝胶素(GS)层状抗氧化系统(GS@L)中的急性心肌梗死。在合成的 GS 框架中观察到固定模块、孔径、吸收、炎症的比例分别为 ka(65 ka)、149 ± 39.8 μm、92.2%、42 ± 1.38 和 29 ± 1.9。在此,制备了 ADSC-GS@L,用于心脏再生应用的相关物质稳定且具有物理化学性质。ADSC-GS@L 可注射冷冻凝胶的评估提高了细胞的存活率,并改善了促血管生成因子和促炎表达,证实了分数射血、纤维面积和血管密度的有利结果,同时减少了梗死尺寸。新型 ADSC 注射冷冻凝胶方法可用于急性心肌梗死期间的成功心脏损伤治疗。此外,该方法可用于冠心病期间的成功心脏损伤治疗。

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