Department of Cardiology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Drug Deliv. 2021 Dec;28(1):1334-1341. doi: 10.1080/10717544.2021.1943060.
Adipose-derived stem cells (ADSCs) treatment offers support to new methods of transporting baseline cell protein endothelial cells in alginate (A)/silk sericin (SS) lamellar-coated antioxidant system (ASS@L) to promote acute myocardial infarction. In the synthesized frames of ASS, the ratio of fixity modules, pores, the absorption and inflammation was detected at ka (65ka), 151 ± 40.12 μm, 92.8%, 43.2 ± 2.58 and 30.10 ± 2.1. In this context, ADSC-ASS@L was developed and the corresponding material was stable and physically chemical for the development of cardiac regenerative applications. ADSC-ASS@L injectable hydrogels in vitro examination demonstrated higher cell survival rates and pro-angiogenic and pro-Inflammatory expression factors, demonstrating the favorable effect of fractional ejections, fibre-areas, and low infracture vessel densities. In successful cardiac damage therapy in acute myocardial infarction the innovative ADSC injection hydrogel approach may be helpful. The approach could also be effective during coronary artery hypertrophy for successful heart damage treatment.
脂肪来源干细胞（ADSCs）治疗为将基础细胞蛋白内皮细胞输送到藻酸盐（A）/丝胶（SS）层状涂层抗氧化系统（ASS@L）中的新方法提供支持，以促进急性心肌梗死。在 ASS 的合成框架中，固定模块的比例、孔、吸收和炎症在 ka（65ka）、151±40.12μm、92.8%、43.2±2.58 和 30.10±2.1 处进行了检测。在此背景下，开发了 ADSC-ASS@L，相应的材料稳定且具有物理化学性质，可用于开发心脏再生应用。ADSC-ASS@L 可注射水凝胶的体外研究表明，细胞存活率和促血管生成及促炎表达因子更高，表明分数射血、纤维面积和低梗死血管密度具有良好的效果。在急性心肌梗死的成功心脏损伤治疗中，创新的 ADSC 注射水凝胶方法可能会有所帮助。该方法在冠状动脉肥大期间也可能对成功的心脏损伤治疗有效。
