低剂量皮质类固醇联合硫唑嘌呤治疗老年发病 IgA 血管炎肾炎的疗效和安全性。
Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.
机构信息
Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Japan
Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Japan.
出版信息
BMJ Case Rep. 2021 Jun 2;14(6):e241422. doi: 10.1136/bcr-2020-241422.
Abstract
The diagnosis of elderly-onset IgA vasculitis (IgAV) and its prognosis can be difficult to ascertain because of its rarity and the frequent presence of comorbidities. Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Renal involvement was detected early during the IgAV follow-up. He was treated with low-dose corticosteroid and azathioprine, which led to a complete remission without any adverse effects. This suggests that precise intervention with early diagnosis and careful renal follow-up may prevent renal failure and that low-dose steroids with azathioprine can be an effective treatment for elderly-onset IgAV with nephritis.
摘要
老年发病 IgA 血管炎（IgAV）的诊断及其预后较难确定，这是因为其发病率低且常合并多种合并症。此外，老年发病 IgAV 的治疗仍存在争议。我们报告了一例 87 岁老年 IgAV 患者。在 IgAV 随访过程中，患者早期即出现肾脏受累。他接受了小剂量皮质类固醇和硫唑嘌呤治疗，病情完全缓解，且无任何不良反应。这表明，早期诊断和密切肾脏随访的精确干预可能预防肾衰竭，并且小剂量类固醇联合硫唑嘌呤治疗老年发病 IgAV 合并肾炎是一种有效的治疗方法。
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