Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
Anticancer Res. 2021 Jun;41(6):2841-2848. doi: 10.21873/anticanres.15065.
BACKGROUND/AIM: Expression of human leukocyte antigen (HLA) class I and II and CD74, which functions as a chaperone of MHC class II, play essential roles in T-cell recognition. The aim of this study was to elucidate the association between the HLAs and CD74, and their correlation with the infiltrated immune cells in renal cell carcinoma (RCC).
We retrospectively investigated the expression of HLA-A/B/C, HLA-DR, and CD74 in 38 patients with advanced RCC (T3/T4), and evaluated their correlations with CD4 and CD8-positive T-cell infiltration using immunohistochemistry.
The expression of HLA-A/B/C, HLA-DR, and CD74 on cancer cells was observed in 37, 20, and 31 patients, respectively. The density of CD8- and CD4-positive T cells showed a positive correlation with HLA-DR expression. The density of CD4-positive lymphocytes was significantly associated with CD74 expression.
The expression of HLA-DR, rather than CD74, on cancer cells was potentially associated with the anti-cancer immune microenvironment.
背景/目的：人类白细胞抗原（HLA）I 类和 II 类以及 CD74 的表达，CD74 作为 MHC II 类的伴侣分子，在 T 细胞识别中发挥重要作用。本研究旨在阐明 HLA 和 CD74 的相关性及其与肾细胞癌（RCC）中浸润免疫细胞的相关性。
我们回顾性调查了 38 例晚期 RCC（T3/T4）患者中 HLA-A/B/C、HLA-DR 和 CD74 的表达，并通过免疫组织化学评估了它们与 CD4 和 CD8 阳性 T 细胞浸润的相关性。
在 37、20 和 31 例患者中分别观察到癌细胞上 HLA-A/B/C、HLA-DR 和 CD74 的表达。CD8-和 CD4 阳性 T 细胞的密度与 HLA-DR 表达呈正相关。CD4 阳性淋巴细胞的密度与 CD74 表达显著相关。
癌细胞上 HLA-DR 的表达而非 CD74 的表达可能与抗肿瘤免疫微环境相关。
