肾细胞癌上的MHC II类抗原相关恒定链可能有助于宿主的抗肿瘤免疫反应。

MHC class II antigen-associated invariant chain on renal cell cancer may contribute to the anti-tumor immune response of the host.

作者信息

Saito T, Kimura M, Kawasaki T, Sato S, Tomita Y

机构信息

Department of Urology, Niigata University School of Medicine, Japan.

出版信息

Cancer Lett. 1996 Dec 3;109(1-2):15-21. doi: 10.1016/s0304-3835(96)04395-9.

DOI:10.1016/s0304-3835(96)04395-9

PMID:9020898

Abstract

To investigate the association between renal cell cancer (RCC) and the host immune system, we examined the expression of invariant chain (Ii) and HLA-DR on renal cancer. Immunohistochemically, Ii was detected in 53 of the 60 cases of RCC. Significant correlation was found between the expression of Ii and the degree of lymphocyte infiltration. Flow cytometric analysis for HLA-DR and Ii on RCC cell line (ACHN) showed no positive cells, whereas interferon (IFN)-K treatment induced HLA-DR. Immunoprecipitation showed the presence of cytoplasmic Ii in ACHN cells. In addition, IFN-K-treated ACHN cells showed more intense signals than untreated cells. These results suggest that Ii associated with class II antigens on RCC may contribute to the anti-tumor immune response of the host and that IFN-K, which is administered for the treatment of cancer, may increase the immunogenicity of RCC.

摘要

为了研究肾细胞癌（RCC）与宿主免疫系统之间的关联，我们检测了肾癌中恒定链（Ii）和HLA - DR的表达。免疫组织化学检测发现，60例RCC中有53例检测到Ii。Ii的表达与淋巴细胞浸润程度之间存在显著相关性。对肾癌细胞系（ACHN）进行HLA - DR和Ii的流式细胞术分析未发现阳性细胞，而干扰素（IFN）-K处理可诱导HLA - DR表达。免疫沉淀显示ACHN细胞中存在细胞质Ii。此外，IFN - K处理的ACHN细胞比未处理的细胞显示出更强的信号。这些结果表明，RCC上与II类抗原相关的Ii可能有助于宿主的抗肿瘤免疫反应，并且用于癌症治疗的IFN - K可能会增加RCC的免疫原性。