新型冠状病毒2型感染中的性别二态性。
Sexual dimorphism in SARS-COV-2 infection.
作者信息
Ulhaq Z S, Soraya G V, Zambrano L E A, Garcia C P
机构信息
Maulana Malik Ibrahim State Islamic University of Malang - Faculty of Medicine and Health Sciences, Malang, East Java, Indonesia, United Kingdom of Great Britain and Northern Ireland.
Hasanuddin University - Faculty of Medicine, Makassar, South Sulawesi, Indonesia, United Kingdom of Great Britain and Northern Ireland.
出版信息
Acta Endocrinol (Buchar). 2020 Oct-Dec;16(4):522-523. doi: 10.4183/aeb.2020.522.
Previous studies have demonstrated that female patients with coronavirus disease 2019 (COVID-19) demonstrate more favorable prognosis relative to male patients. In this article, we elaborate the possible role of estrogen in the modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection severity. The potential interplay between several factors, including inherently lower estradiol (E) and slightly higher estrogen receptor β (ERβ) levels in males, with inflammatory mediators are described. Altogether, there seems to be a sexually dimorphic response towards SARS-CoV-2 infection, and a possibility that COVID-19 severity is dependent on both E levels and ERα:ERβ expression ratio in lymphoid and lung cells.
先前的研究表明，2019冠状病毒病（COVID-19）女性患者的预后相对于男性患者更为良好。在本文中，我们阐述了雌激素在调节严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染严重程度方面可能发挥的作用。描述了包括男性体内固有较低的雌二醇（E）水平和略高的雌激素受体β（ERβ）水平在内的多种因素与炎症介质之间的潜在相互作用。总体而言，对于SARS-CoV-2感染似乎存在性别差异反应，并且COVID-19的严重程度有可能取决于淋巴细胞和肺细胞中的E水平以及ERα:ERβ表达比率。
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