Osborne B, Markgraf C
Department of Psychology, Middlebury College, Vermont 05753.
Behav Neural Biol. 1988 May;49(3):249-60. doi: 10.1016/s0163-1047(88)90226-9.
The present experiment examined spatial and response variation interpretations of the large difference in magnitude between operant and instrumental extinction deficits seen in hipocampally damaged animals. Latency measures and detailed behaviors of rats with fornix transections were compared to those of control rats during acquisition and extinction in an enriched spatial runway. Control rats, in comparison to rats with fornix transections, exhibited larger increases in start box, runway, and goal box latencies, but no spatial gradients were found. Control rats also exhibited less goal persistence and more response variation following the transition to extinction. The results suggest no fundamental difference between operant and instrumental deficits following hippocampal damage, but an interaction between strategies employed and traditional response measures.
本实验研究了海马损伤动物在操作性消退和工具性消退缺陷之间幅度上的巨大差异的空间和反应变异性解释。在丰富的空间跑道上进行习得和消退期间，将穹窿横断大鼠的潜伏期测量和详细行为与对照大鼠进行了比较。与穹窿横断大鼠相比，对照大鼠在起始箱、跑道和目标箱的潜伏期增加更大，但未发现空间梯度。对照大鼠在过渡到消退后也表现出较少的目标持续性和更多的反应变异性。结果表明，海马损伤后操作性缺陷和工具性缺陷之间没有根本差异，但所采用的策略与传统反应测量之间存在相互作用。
