正常血压和高血压大鼠的听觉惊吓反应

Auditory startle in normotensive and hypertensive rats.

作者信息

Sutterer J R, McSparren J, Ingerman B

机构信息

Department of Psychology, Syracuse University, New York 13210.

出版信息

Behav Neural Biol. 1988 May;49(3):310-4. doi: 10.1016/s0163-1047(88)90306-8.

DOI:10.1016/s0163-1047(88)90306-8

PMID:3408443

Abstract

In the present experiment auditory startle was examined in male and female rats of the spontaneously hypertensive (SHR) and Wistar-Kyoto normotensive (WKY) strains and borderline hypertensive rats (BHR) derived from cross-breeding SHR females with WKY males. The magnitude of auditory startle declined over trials and was significantly higher in WKYs than in both SHRs and BHRs which did not differ from each other. These data add to an increasing body of literature concerning behavioral differences between hypertensive and normotensive rats and are discussed as they relate to the possible strain differences in either behavioral reactivity or tonic fear.

摘要

在本实验中，对自发性高血压（SHR）和Wistar-Kyoto正常血压（WKY）品系的雄性和雌性大鼠，以及通过将SHR雌性大鼠与WKY雄性大鼠杂交培育出的临界高血压大鼠（BHR）进行了听觉惊吓反应测试。听觉惊吓反应的幅度在多次试验中逐渐下降，且WKY大鼠的反应幅度显著高于SHR大鼠和BHR大鼠，而后两者之间无差异。这些数据进一步丰富了有关高血压大鼠和正常血压大鼠行为差异的文献，并就其与行为反应性或紧张性恐惧方面可能存在的品系差异的关系进行了讨论。