Sutterer J R, Stoney C M, Sanfillipo M
Hypertension. 1984 Nov-Dec;6(6 Pt 1):868-76. doi: 10.1161/01.hyp.6.6.868.
This study investigated the behavior of hypertensive-prone and nonhypertensive-prone rat strains to see whether there are differences in behavioral reactivity to environmental stimulation. Of primary interest was general activity, because investigators have assumed it to be an index of reactivity to environmental stimulation and to be correlated with the elevation of blood pressure in spontaneously hypertensive rats (SHR) but not in normotensive Wistar-Kyoto (WKY) rats. Therefore, general activity was assessed in SHRs and WKYs as a function of walking and rearing in an open field (Experiments 1 and 2) and crossings in a shuttlebox test (Experiments 3, 4, and 5). Activity was assessed under a constant level of environmental stimulation in the open field (Experiment 1) and shuttlebox (Experiment 3) or under varying degrees of stimulation in the open field (Experiment 2) and shuttlebox (Experiments 4 and 5). In the open field and the shuttlebox, SHR activity was above WKY activity when the degree of environmental stimulation was constant. However, when stimulation was manipulated, the SHR activity level was similar for all intensity levels, while the WKY activity was inversely related to stimulus intensity. These results suggest that while the SHRs may generally be more active than WKYs, WKYs display a greater behavioral reactivity to environmental stimulation than SHRs.
本研究调查了高血压倾向和非高血压倾向大鼠品系的行为，以观察它们对环境刺激的行为反应是否存在差异。主要关注的是一般活动，因为研究人员认为它是对环境刺激反应的一个指标，并且与自发性高血压大鼠（SHR）的血压升高相关，但与正常血压的Wistar-Kyoto（WKY）大鼠无关。因此，在SHR和WKY中，通过在旷场中行走和竖起来评估一般活动（实验1和2），并在穿梭箱试验中评估穿越次数（实验3、4和5）。在旷场（实验1）和穿梭箱（实验3）中，在恒定水平的环境刺激下评估活动，或者在旷场（实验2）和穿梭箱（实验4和5）中在不同程度的刺激下评估活动。在旷场和穿梭箱中，当环境刺激程度恒定时，SHR的活动高于WKY的活动。然而，当刺激被操纵时，SHR的活动水平在所有强度水平上相似，而WKY的活动与刺激强度呈负相关。这些结果表明，虽然SHR通常可能比WKY更活跃，但WKY对环境刺激的行为反应比SHR更大。
