Wang Qinhong
CAS Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
Sheng Wu Gong Cheng Xue Bao. 2021 May 25;37(5):1471-1476. doi: 10.13345/j.cjb.210289.
Metabolic engineering is the use of recombinant DNA technology, synthetic biology and genome editing to modify the cellular networks including metabolic, gene regulatory, and signaling networks of an organism. It can achieve the desirable goals such as enhanced production of metabolites, and improve the capability of biomanufacturing pharmaceuticals, biofuels and biochemicals as well as other biotechnology products. In order to comprehend the status of metabolic engineering in past 30 years, we published this special issue to review the progress and trends of metabolic engineering from the four aspects of overall development, key technologies, host engineering and product engineering, respectively, for laying the foundation for the further development of metabolic engineering.
代谢工程是指利用重组DNA技术、合成生物学和基因组编辑来修饰生物体的细胞网络，包括代谢、基因调控和信号网络。它可以实现诸如提高代谢物产量等理想目标，并提高生物制造药物、生物燃料和生化制品以及其他生物技术产品的能力。为了了解过去30年代谢工程的发展状况，我们出版了这一特刊，分别从整体发展、关键技术、宿主工程和产品工程四个方面综述代谢工程的进展和趋势，为代谢工程的进一步发展奠定基础。
