Wang Jing-Jing, Wang Xiao-Yu, Zhang Xiao-Ning, Wang Guang-Jun, Pu Rong, Chen Li-Zhen, Chen Zhong-Jie, Zhou Jin-Cao, Zhang Yi, Wang Wen-Yan
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Eighth Medical Center, Chinese PLA General Hospital.
Zhongguo Zhen Jiu. 2021 Jun 12;41(6):615-20. doi: 10.13703/j.0255-2930.20201004-k0001.
To observe the effect of five-element acupuncture on the cognitive function repair of migraine patients with depression/anxiety disorder.
The migraine patients with depression/anxiety disorder (19 cases, 5 cases dropped off) were taken as the observation group, and received five-element acupuncture twice a week for 8 weeks. Healthy subjects (19 cases) were selected by demographic data matching as the control group. The cognitive function was evaluated with the event related potential (ERP) technique, and the latency and amplitude of visual evoked potential P300 were adopted as the observation indexes. The headache days (every 4 weeks), headache intensity [visual analogue scale(VAS) score], and headache impact test-6 (HIT-6) score, Hamilton depression scale (HAMD) score and Hamilton anxiety scale (HAMA) score were used as the observation indexes for curative effect.
Before the treatment, latency of target stimulus at Fz [ (417.5±34.3) ms] in the observation group was extended compared with the healthy subjects of the control group [(388.6±42.1) ms, <0.05]. In the observation group, the latency of each point target stimulus [Fz: (376.1±36.2) ms, F3: (374.8±37.6) ms, F4: (372.0±37.6) ms] after treatment were shorter than those [Fz: (417.5±34.3) ms, F3: (417.4±33.8) ms, F4: (416.0±36.6) ms] before treatment (<0.05). Before and after treatment, there was no significant difference in the amplitude of each point between the observation group and the control group (>0.05). In the observation group, the headache days was shorter than that before treatment (<0.01), and the VAS score, HIT-6 score, HAMD score and HAMA score were all lower than before treatment (<0.01).
There are some cognitive impairments in migraine patients with depression/anxiety disorder. Five-element acupuncture not only relieves headache, anxiety and depression effectively, but also improves the activation level of the frontal lobe. It significantly repairs the impaired cognitive function.
观察五行针灸对伴发抑郁/焦虑障碍的偏头痛患者认知功能修复的影响。
将伴发抑郁/焦虑障碍的偏头痛患者（19例，脱落5例）作为观察组，每周接受2次五行针灸治疗，共8周。通过人口统计学数据匹配选取健康受试者（19例）作为对照组。采用事件相关电位（ERP）技术评估认知功能，以视觉诱发电位P300的潜伏期和波幅作为观察指标。以头痛天数（每4周）、头痛强度[视觉模拟量表（VAS）评分]、头痛影响测试-6（HIT-6）评分、汉密尔顿抑郁量表（HAMD）评分和汉密尔顿焦虑量表（HAMA）评分作为疗效观察指标。
治疗前，观察组Fz点目标刺激潜伏期[（417.5±34.3）ms]较对照组健康受试者[（388.6±42.1）ms]延长（P<0.05）。观察组治疗后各点目标刺激潜伏期[Fz：（376.1±36.2）ms，F3：（374.8±37.6）ms，F4：（372.0±37.6）ms]均短于治疗前[Fz：（417.5±34.3）ms，F3：（417.4±33.8）ms，F4：（416.0±36.6）ms]（P<0.05）。治疗前后，观察组与对照组各点波幅比较，差异无统计学意义（P>0.05）。观察组头痛天数少于治疗前（P<0.01），VAS评分、HIT-6评分、HAMD评分和HAMA评分均低于治疗前（P<0.01）。
伴发抑郁/焦虑障碍的偏头痛患者存在一定认知损害。五行针灸不仅能有效缓解头痛、焦虑和抑郁，还能提高额叶激活水平，显著修复受损的认知功能。
