Institute of General and Experimental Biology SB RAS, Ulan-Ude, Russia.
Nat Prod Res. 2022 Jun;36(12):3105-3109. doi: 10.1080/14786419.2021.1935932. Epub 2021 Jun 4.
The antihypoxic effect of the Nepeta multifida L. dry extract was studied in experiments on white Wistar rats. The life span of animals was determined against the background of acute hypoxias: hypercapnic, hemic, and histotoxic ones. Using the model of acute hypobaric hypoxia/reoxygenation there was evaluated the content of ATP, lactic and pyruvic acids, TBA-active products, reduced glutathione, catalase activity in brain tissue. On the model of acute hypobaric hypoxia/reoxygenation, the content of ATP, lactic and pyruvic acids, reduced glutathione and catalase activity in brain tissue The N. multifida dry extract demonstrated antihypoxic effect at the doses comprised between 100 and 300 mg/kg increasing lifespan of animals in hypercapnic, hemic and histotoxic hypoxias. decreases the manifestation of free-radical oxidation processes, increases the activity of the endogenic antioxidant system, and promotes the efficacy of tissue respiration and oxidative phosphorylation coupling in the brain of white rats in hypoxia/reoxygenation.
用小白鼠进行实验研究了荆芥干提取物的抗缺氧作用。在急性缺氧（高碳酸血症性、低血氧性和化学中毒性）背景下，测定了动物的寿命。利用急性低压缺氧/复氧模型，评估了脑组织中 ATP、乳酸和丙酮酸、TBA 活性产物、还原型谷胱甘肽、过氧化氢酶活性的含量。在急性低压缺氧/复氧模型中，荆芥干提取物在 100-300mg/kg 剂量下表现出抗缺氧作用，可延长高碳酸血症性、低血氧性和化学中毒性缺氧动物的寿命。降低自由基氧化过程的表现，增加内源性抗氧化系统的活性，促进缺氧/复氧时大鼠脑组织的组织呼吸和氧化磷酸化偶联的功效。
