Endocrinology Unit, Medical Department, Azienda Usl, Maggiore-Bellaria Hospital, Bologna, Italy.
Andrology, Women's Endocrinology and Gender Incongruence Unit, Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Expert Rev Clin Pharmacol. 2021 Sep;14(9):1091-1103. doi: 10.1080/17512433.2021.1938548. Epub 2021 Jun 21.
The specific role of testosterone [T] replacement therapy [TRT] on glycometabolic profile and body composition, particularly in patients with metabolic syndrome [MetS] and/or type 2 diabetes mellitus [T2DM], is still the object of an intense debate.
To discuss available evidence on the association between T and metabolic diseases and on the possible effect of T administration on metabolic disorder-associated hypogonadism. Both preclinical and clinical data have been considered. In addition, a meta-analysis of the available placebo and non-placebo-controlled randomized clinical trials [RCTs] investigating the effects of TRT in T2DM or MetS in several outcomes has been also performed.
Data derived from preclinical and clinical studies suggest that T administration, by reducing fat mass, can improve body composition and ameliorate some aspects of glucose metabolism. The effects of TRT on sexual function in patients with established metabolic derangements are inconsistent, whereas better results were observed in preclinical conditions or in patients with newly diagnosed T2DM.
睾酮[T]替代疗法[TRT]对糖代谢谱和身体成分的具体作用，特别是在代谢综合征[MetS]和/或 2 型糖尿病[T2DM]患者中，仍然是激烈争论的对象。
讨论 T 与代谢疾病之间的关联以及 T 给药对与代谢紊乱相关的性腺功能减退症的可能影响的现有证据。考虑了临床前和临床数据。此外，还对现有的安慰剂和非安慰剂对照随机临床试验[RCT]进行了荟萃分析，这些 RCT 研究了 TRT 在 T2DM 或 MetS 中对多种结局的影响。
来自临床前和临床研究的数据表明，T 给药通过减少脂肪量，可以改善身体成分并改善某些方面的葡萄糖代谢。TRT 对已存在代谢紊乱患者的性功能的影响不一致，而在临床前条件下或在新诊断为 T2DM 的患者中观察到了更好的结果。
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