Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China, Hefei 230026, China.
College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang Province 325035, China.
Chem Commun (Camb). 2021 Jun 29;57(52):6400-6403. doi: 10.1039/d1cc01620b.
Borylative difunctionalization of alkenes has emerged as a powerful approach for synthesizing highly functionalized molecules. Herein, dual Cu/Pd-catalysed borylfluoroallylation of alkenes was smoothly achieved by using gem-difluorinated cyclopropanes and B2pin2, providing the corresponding monofluoroalkene scaffolds in moderate to high yields with excellent stereoselectivity. Moreover, an array of synthetic building blocks can be obtained by downstream transformations.
硼芳基化双官能化反应已成为合成高度功能化分子的有力方法。本文通过使用偕二氟环丙烷和 B2pin2，实现了双 Cu/Pd 催化的烯烃硼氟烯丙基化反应，以中等至较高的收率和优异的立体选择性得到了相应的单氟烯烃骨架。此外，通过下游转化可以获得一系列合成砌块。
