Ural Federal University, Yekaterinburg, Russia.
Omsk Research Institute of Natural Foci Infections, Omsk, Russia.
Virus Genes. 2021 Aug;57(4):395-399. doi: 10.1007/s11262-021-01849-6. Epub 2021 Jun 4.
According to modern classification, tick-borne flaviviruses have been divided into a mammalian tick-borne virus group and a seabird tick-borne virus group (STBVG). The STBVG includes the Tyuleniy virus, Meaban virus, Saumarez Reef virus, and the recently discovered Kama virus (KAMV). The latter was isolated from Ixodes lividus, an obligate parasitic tick of the sand martin (Riparia riparia), in 1989 in the central part of the Russian Plain. In 2014, based on molecular genetic analysis, it was shown that KAMV is a new virus belonging to STBVG, genus Flavivirus, fam. Flaviviridae. Very little is known about the Kama virus concerning its range, vectors, and reservoir hosts. GenBank contains a single sequence of the complete genome of this virus. In the present study, the complete genome sequences of two strains, isolated in 1983 in the Omsk region (Western Siberia) from gamasid mites in the nests of rooks (Corvus frugilegus), have been determined. Phylogenetic analyses of their genomes showed a close relationship both with each other (approx. 98.9% nucleotide identity) and with KAMV isolated in European Russia (approx. 98.4% nucleotide identity). The ecological features of KAMV that are due to the species of the vector (gamasid mites) and its hosts (colonial birds of the mainland of Eurasia) indicate that KAMV is an atypical representative STBVG.
根据现代分类，蜱传黄病毒已分为哺乳动物蜱传病毒群和海鸟蜱传病毒群（STBVG）。STBVG 包括 Tyuleniy 病毒、Meaban 病毒、Saumarez Reef 病毒和最近发现的 Kama 病毒（KAMV）。后者于 1989 年在俄罗斯平原中部从沙马丁（Riparia riparia）的专性寄生蜱Ixodes lividus 中分离出来。2014 年，基于分子遗传分析表明，KAMV 是一种属于 STBVG、黄病毒属、黄病毒科的新病毒。关于 Kama 病毒的范围、载体和储存宿主知之甚少。GenBank 中仅包含该病毒完整基因组的单个序列。在本研究中，确定了 1983 年在奥姆斯克地区（西西伯利亚）从红嘴山鸦（Corvus frugilegus）巢中的革螨中分离出的两种病毒株的完整基因组序列。对其基因组的系统进化分析表明，它们彼此之间以及与在俄罗斯欧洲部分分离的 KAMV 之间的关系非常密切（约 98.9%核苷酸同一性）。KAMV 的生态特征与其载体（革螨）和宿主（欧亚大陆大陆的群居鸟类）的种类有关，表明 KAMV 是一种非典型的 STBVG 代表。
