School of Life Sciences, Nantong University, Nantong, China.
Centro Nacional de Biotecnología, CSIC, Madrid, Spain.
Pest Manag Sci. 2021 Oct;77(10):4564-4571. doi: 10.1002/ps.6495. Epub 2021 Jun 22.
Ceratocystis fimbriata is a hazardous fungal pathogen able to cause black rot disease on sweet potato. The management of C. fimbriata strongly relies on the use of toxic fungicides, and there is a lack of efficient alternative strategies.
The antifungal properties of quinolinic acid (QA) were studied for the first time, indicating that QA shows selective antifungal activity against C. fimbriata. QA inhibited completely the mycelial growth of C. fimbriata at less than 0.8 mg mL concentration (pH 4), and was able to produce alterations in the fungal cell wall, and to impede spore agglutination and mycelium formation. QA significantly reduced the concentration of ergosterol, and was able to associate to iron (II), suggesting that QA may be a lanosterol 14-α demethylase inhibitor. In preventive applications, QA reduced the disease incidence of C. fimbriata on sweet potato by 75%, achieving higher control efficacy in comparison with commercial fungicides prochloraz and carbendazim.
The first selective antifungal agent against C. fimbriata was discovered in this work, and showed suitable antifungal properties for the management of black rot disease. © 2021 Society of Chemical Industry.
棘壳孢菌是一种危险的真菌病原体，能够引起甘薯黑斑病。棘壳孢菌的防治主要依赖于有毒杀菌剂的使用，而缺乏有效的替代策略。
首次研究了喹啉酸（QA）的抗真菌特性，表明 QA 对棘壳孢菌表现出选择性的抗真菌活性。QA 在低于 0.8mg/mL 浓度（pH4）时完全抑制棘壳孢菌的菌丝生长，能够改变真菌细胞壁，并阻碍孢子聚集和菌丝形成。QA 显著降低了麦角固醇的浓度，并能够与铁（II）结合，表明 QA 可能是一种羊毛甾醇 14-α 脱甲基酶抑制剂。在预防性应用中，QA 降低了甘薯上棘壳孢菌的发病率 75%，与商业杀菌剂丙环唑和多菌灵相比，具有更高的防治效果。
本研究首次发现了一种针对棘壳孢菌的选择性抗真菌剂，具有防治黑斑病的适宜抗真菌特性。© 2021 化学工业协会。
