Birmingham/Atlanta Geriatric Research, Education, and Clinical Center (GRECC), Department of Veterans Affairs, Birmingham, AL; University of Alabama at Birmingham, School of Medicine, Department of Medicine.
University of Alabama at Birmingham, School of Medicine, Department of Medicine.
Urology. 2021 Dec;158:88-94. doi: 10.1016/j.urology.2021.05.032. Epub 2021 Jun 2.
To operationalize a new definition for bladder health, we examined the distribution of lower urinary tract symptoms (LUTS) and impact, along with associated factors, among women in the Coronary Artery Risk Development in Young Adults (CARDIA) study.
We performed cluster analyses using validated LUTS symptom burden and impact scales collected between 2005-2006 and 2010-2011. We performed multinomial logistic regression analyses to evaluate cardiovascular factors (metabolic syndrome, cardiovascular health behaviors, and inflammation) between clusters after adjusting for covariates (demographic, obstetric/gynecologic, co-morbidities).
Among CARDIA women (median age 51, range 42-59) with complete LUTS data (n = 1302), we identified and compared 4 cluster groups: women who reported no or very mild symptoms and no impact on well-being (bladder health, 44%, n = 569), versus women with LUTS and negative impact on well-being ranging from mild (31%, n = 407), moderate (20%, n = 259), to severe (5%, n = 67). With each 1-point lower BMI (kg/m), odds of membership in mild (OR 0.97, CI 0.95-0.99), moderate (OR 0.95, CI 0.93-0.98), and severe (OR 0.90, CI 0.88-0.94) LUTS cluster groups versus the bladder health group were lower. Compared to women with metabolic syndrome, women without metabolic syndrome had lower odds of membership in mild (OR 0.67, CI 0.45-0.99), moderate (OR 0.51, CI 0.33-0.79), and severe (OR 0.48, CI 0.24-0.94) LUTS cluster groups versus the bladder health group.
Two out of 5 midlife women met our definition of bladder health. Bladder health and cardiovascular health among women may share common factors, including lower BMI and the absence of metabolic syndrome.
为了对新的膀胱健康定义进行操作化，我们检查了在冠状动脉风险发展于年轻人（CARDIA）研究中的女性中，下尿路症状（LUTS）的分布及其影响，以及相关因素。
我们使用在 2005-2006 年和 2010-2011 年之间收集的经过验证的 LUTS 症状负担和影响量表进行聚类分析。我们在调整协变量（人口统计学，产科/妇科，合并症）后，使用多变量逻辑回归分析评估簇间的心血管因素（代谢综合征，心血管健康行为和炎症）。
在 CARDIA 女性（中位年龄 51 岁，范围 42-59 岁）中，有完整的 LUTS 数据（n=1302），我们鉴定并比较了 4 个聚类组：报告无或轻度症状且无幸福感影响的女性（膀胱健康，44%，n=569），与有 LUTS 且幸福感受影响的女性（从轻度到重度），其影响程度从轻度（31%，n=407），中度（20%，n=259）到重度（5%，n=67）。BMI（kg/m）每降低 1 个单位，轻度（OR 0.97，CI 0.95-0.99），中度（OR 0.95，CI 0.93-0.98）和重度（OR 0.90，CI 0.88-0.94）LUTS 聚类组与膀胱健康组相比，其可能性就越低。与患有代谢综合征的女性相比，没有代谢综合征的女性患有轻度（OR 0.67，CI 0.45-0.99），中度（OR 0.51，CI 0.33-0.79）和重度（OR 0.48，CI 0.24-0.94）LUTS 聚类组的可能性也较低。
五分之二的中年女性符合我们的膀胱健康定义。女性的膀胱健康和心血管健康可能具有共同的因素，包括较低的 BMI 和不存在代谢综合征。
