Maslar I A, Lazur J J, Norman R L, Spies H G
Division of Reproductive Biology and Behavior, Oregon Regional Primate Research Center, Beaverton 97006.
Biol Reprod. 1988 Jun;38(5):1067-76. doi: 10.1095/biolreprod38.5.1067.
In rhesus macaques, the concentration of immunoreactive prolactin in the amniotic fluid remains low during most of the first trimester of pregnancy and then increases abruptly at 60-80 days of gestation. During the second half of pregnancy, large amounts of prolactin accumulate in the amniotic fluid. Much of this amniotic fluid prolactin may originate from the superficial endometrium (decidua). This hypothesis is supported by the increasing amounts of decidual prolactin (dPRL) measured in endometrium obtained at early (50 days), mid-(80 days), and late (greater than or equal to 150 days) gestation. In culture, late pregnancy endometrium released more dPRL than did early pregnancy endometrium. When tissues were cultured in medium without progesterone, the amounts of dPRL measured in the medium declined steadily over 6 days, regardless of the gestational age of the endometrium. dPRL was consistently measured in medium harvested from cultures that received either progesterone or medroxyprogesterone; however, progesterone did not induce an increase in the amounts of dPRL released by cultures prepared from early pregnancy endometrium. This suggests that factors in addition to progesterone may stimulate the increase in dPRL that occurs at midgestation in rhesus macaques.
在恒河猴中，羊水内免疫反应性催乳素的浓度在妊娠头三个月的大部分时间里保持较低水平，然后在妊娠60 - 80天时突然升高。在妊娠后半期，大量催乳素在羊水中积聚。这种羊水催乳素大部分可能源自浅表子宫内膜（蜕膜）。在妊娠早期（50天）、中期（80天）和晚期（大于或等于150天）获取的子宫内膜中测得的蜕膜催乳素（dPRL）量不断增加，支持了这一假说。在培养中，妊娠晚期子宫内膜释放的dPRL比妊娠早期子宫内膜更多。当组织在不含孕酮的培养基中培养时，无论子宫内膜的妊娠年龄如何，培养基中测得的dPRL量在6天内稳步下降。在从接受孕酮或甲羟孕酮的培养物中收获的培养基中始终能检测到dPRL；然而，孕酮并未诱导妊娠早期子宫内膜制备的培养物释放的dPRL量增加。这表明除孕酮外的其他因素可能刺激恒河猴妊娠中期发生的dPRL增加。
