Institute of Chemistry, Federal University of Goiás, Goiânia, GO, 74690-900, Brazil.
Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-900, Brazil.
Environ Sci Pollut Res Int. 2021 Oct;28(40):57288-57296. doi: 10.1007/s11356-021-14603-0. Epub 2021 Jun 4.
Concerns about human health regarding the large use of bisphenol A in thermal papers have led to its replacement by bisphenol S. Analyses of bisphenols require several sample pretreatment steps, which are laborious, expensive, and time-consuming. A paper spray ionization mass spectrometry (PSI-MS) was developed to detect and quantify bisphenol S in three different brands of thermal papers commercially available. Parameters such as paper size, and paper position relative to the mass spectrometer inlet were evaluated. The analyses were performed in selected ion monitoring mode on a linear ion trap mass spectrometer. The developed method presented absolute recovery values ranging from 92.2 to 109.04%, accuracy values from -1.2 to 9.0%, and inter assay precision from 1.8 to 5.6% and enabled LOD as low as 5 ng g. The concentration of bisphenol S in all of the three brands of BPA-free thermal papers evaluated ranged from 1.36 to 6.77 μg g, and the concentrarion of BPA ranged from 6.56 to 16.4 μg g in all samples of thermal paper evaluated. The PSI-MS method described here was comparable to the conventional ones, such as liquid chromatography coupled with mass spectrometry and gas chromatography coupled with mass spectrometry described in the literature. The present study proved to be practical, fast, and efficient for the direct determination of bisphenol S in thermal papers. Furthermore, the methodology here described showed to be a promising alternative to replace the classical methods for determination of bisphenol S, due to its simplicity, and no needing of any sample pretreatment.
人们对热纸中大量使用双酚 A 对人体健康的担忧促使其被双酚 S 所取代。双酚的分析需要经过几个样品预处理步骤，这些步骤既繁琐、昂贵又耗时。本文开发了一种纸喷雾电离质谱（PSI-MS），用于检测和定量分析三种市售的无 BPA 热纸中的双酚 S。评估了纸张尺寸以及纸张相对于质谱仪入口的位置等参数。在配备线性离子阱质谱仪的选择离子监测模式下进行分析。所开发的方法的绝对回收率值范围为 92.2%至 109.04%，准确度值范围为-1.2%至 9.0%，批内精密度范围为 1.8%至 5.6%，LOD 低至 5ng g。评估的三种无 BPA 热纸中双酚 S 的浓度范围为 1.36 至 6.77μg g，评估的所有热纸样品中双酚 A 的浓度范围为 6.56 至 16.4μg g。本文描述的 PSI-MS 方法与文献中报道的传统方法（如液相色谱-质谱联用和气相色谱-质谱联用）相当。本研究证明，对于直接测定热纸中的双酚 S，该方法实用、快速且高效。此外，由于其简单性，不需要任何样品预处理，本文所描述的方法有望成为替代经典方法测定双酚 S 的有前途的方法。
