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女性死亡率与其生育史的关系。

Mortality in women in relation to their childbearing history.

作者信息

Green A, Beral V, Moser K

机构信息

Department of Epidemiology, London School of Hygiene and Tropical Medicine.

出版信息

BMJ. 1988 Aug 6;297(6645):391-5. doi: 10.1136/bmj.297.6645.391.

Abstract

With data from the Office of Population Censuses and Surveys' longitudinal study the mortality of currently married women aged under 60 in 1971 was investigated in relation to the number of liveborn children reported at the 1971 census, adjusting for their husbands' social class. Women who had never had children experienced a higher mortality from many causes of death than the parous women, and this was probably due, at least in part, to selective factors. When the analysis was confined to parous women mortality from diabetes mellitus and cervical cancer increased significantly and oesophageal cancer decreased significantly with increasing number of liveborn children. Mortality from all circulatory diseases and from hypertensive disease, ischaemic heart disease, and subarachnoid haemorrhage tended to rise with parity, though the trends were not statistically significant. Mortality from breast cancer decreased significantly with the number of liveborn children, but only when nullipara were included in the analyses. These data suggest that there may be residual and cumulative effects of childbearing which influence patterns of disease in the long term.

摘要

利用人口普查与调查办公室纵向研究的数据,对1971年60岁以下已婚妇女的死亡率与1971年人口普查报告的活产子女数量之间的关系进行了调查,并根据其丈夫的社会阶层进行了调整。从未生育过子女的妇女因多种死因导致的死亡率高于经产妇女,这可能至少部分归因于选择因素。当分析仅限于经产妇女时,糖尿病和宫颈癌导致的死亡率随着活产子女数量的增加而显著上升,而食管癌导致的死亡率则显著下降。所有循环系统疾病以及高血压疾病、缺血性心脏病和蛛网膜下腔出血导致的死亡率往往随着产次的增加而上升,尽管这些趋势在统计学上并不显著。乳腺癌导致的死亡率随着活产子女数量的增加而显著下降,但只有在分析中纳入未生育妇女时才会如此。这些数据表明,生育可能存在残留和累积效应,会长期影响疾病模式。

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