Institute of Public Health, National Yang-Ming University, Taipei, Taiwan, Republic of China; Department of Chinese Medicine, Taipei City Hospital, Renai Branch, Taipei, Taiwan, Republic of China; General Education Center, University of Taipei, Taipei, Taiwan, Republic of China.
Department of Chinese Medicine, Taipei City Hospital, Renai Branch, Taipei, Taiwan, Republic of China; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, Republic of China.
J Ethnopharmacol. 2021 Oct 5;278:114291. doi: 10.1016/j.jep.2021.114291. Epub 2021 Jun 3.
Major depression is an important risk factor for dementia. Traditional Chinese medicine (TCM) can alleviate the symptoms of major depression. However, it is unclear whether TCM decreases the risk of dementia in patients with major depression. Therefore, in this nationwide case-control study, we aimed to evaluate the association between TCM and the risk of dementia.
We included 31,981 major depression patients with dementia from the National Dementia Database as the case group, and 4391 major depression patients without dementia from a one-million random sample database as the control group. We matched age (plus or minus two years), sex, and year of depression diagnosis based on a 1:4 ratio.
There were 11,724 and 2931 patients in the case and control groups, respectively. Based on a conditional logistic regression analysis, the TCM groups exhibited significantly lower odds ratios with a 95% confidence interval of 0.83 (0.74-0.91). TCM treatment for more than 90 days, dispersing Qi, and activating blood circulation resulted in lower dementia risk with the following odds ratios and 95% confidence intervals: 0.60 (0.56-0.68), 0.87 (0.74-1.08), and 0.66 (0.49-0.81).
The results suggest that TCM is associated with lower dementia risk in major depression patients.
重度抑郁症是痴呆的重要危险因素。传统中医（TCM）可以缓解重度抑郁症的症状。然而，目前尚不清楚 TCM 是否会降低重度抑郁症患者患痴呆症的风险。因此，在这项全国范围内的病例对照研究中，我们旨在评估 TCM 与痴呆症风险之间的关联。
我们将来自国家痴呆症数据库的 31981 例痴呆症重度抑郁症患者纳入病例组，将来自一百万人随机样本数据库的 4391 例无痴呆症的重度抑郁症患者纳入对照组。我们根据 1:4 的比例匹配年龄（正负两年）、性别和抑郁诊断年份。
病例组和对照组分别有 11724 例和 2931 例患者。基于条件逻辑回归分析，TCM 组的优势比显著降低，95%置信区间为 0.83（0.74-0.91）。TCM 治疗超过 90 天、理气活血治疗可降低痴呆风险，其优势比和 95%置信区间分别为 0.60（0.56-0.68）、0.87（0.74-1.08）和 0.66（0.49-0.81）。
结果表明，TCM 与重度抑郁症患者的痴呆风险降低有关。
