Mailleux P, Vanderhaeghen J J
Laboratory of Neuropathology, Erasme Hospital, Université Libre de Bruxelles, Belgium.
Brain Res. 1988 Jul 19;456(1):199-203. doi: 10.1016/0006-8993(88)90364-2.
A large number of transient neurotensin-immunoreactive nerve terminals are found in the human principal inferior olive of the medulla oblongata during the first year of age and almost completely disappear in the adult. Their neurotensin content is further characterized as neurotensin(1-13) using radioimmunoassay and gel filtration and reaches 582 pmol per gram wet weight at 6 months. Neurotensin nerve terminals are exclusively located in the principal olive and a dense bundle of neurotensin nerve fibers is also present in the central tegmental tract. Thus, these olivary neurotensin nerve terminals probably originate in mesencephalic neurons. In addition to its recognized role in neurotransmission or neuromodulation, neurotensin may thus also be implicated in the postnatal development of the human principal olive and indirectly in that of the neocerebellum.
在出生后的第一年，人类延髓的主要下橄榄核中发现大量短暂的神经降压素免疫反应性神经末梢，而在成年人中几乎完全消失。利用放射免疫分析和凝胶过滤法进一步确定其神经降压素含量为神经降压素（1-13），在6个月时达到每克湿重582皮摩尔。神经降压素神经末梢仅位于主要橄榄核，中央被盖束中也存在一束密集的神经降压素神经纤维。因此，这些橄榄核神经降压素神经末梢可能起源于中脑神经元。除了其在神经传递或神经调节中公认的作用外，神经降压素还可能参与人类主要橄榄核的出生后发育，并间接参与新小脑的发育。
