PhD. Doctor in Podiatric Medicine. Biomedical Sciences Department, Extremadura University, Extremadura Spain.
PhD. Doctor in Podiatric Medicine. Nursery Department, Castilla-Mancha University, Toledo Spain.
J Tissue Viability. 2021 Nov;30(4):608-611. doi: 10.1016/j.jtv.2021.05.001. Epub 2021 May 24.
The skin is the body's outermost organ, and one of its main functions is to provide protection against potential infections. Hydration is related to the proper functioning of the skin, hindering the appearance of wounds or cracks which could lead to the occurrence of infections or other dermatological alterations. The skin of the foot is thicker than that of the rest of the body due to the load it supports, and it is more complicated to maintain. The intention of this study was to evaluate the efficacy of different concentrations of urea (5% and 20%) in hydrating the foot compared to a placebo cream.
The study was carried out with 60 subjects of ages from 20 to 35 years in age. The experimental protocol was initiated by creating three randomized groups (1:1:1), each being treated with a different cream: placebo, 5% urea cream, and 20% urea cream. The examination was carried out using a non-invasive instrument (Corneometer CM 825®) that detects the skin surface hydration.
Analysis of the hydration of the different study zones according to the cream used showed no significant differences between the placebo and 5% urea for the first MTH and heel, but a significant difference for the fifth MTH. There were significant differences in all study areas between the placebo and 20% urea creams, but none between the 5% urea and 20% DISCUSSION/CONCLUSION: The conclusion drawn was that skin hydration was greater with the 20% urea cream versus the placebo, but there were no differences found when comparing either the 20% and 5% urea creams or the placebo and 5% urea creams.
皮肤是人体的最外层器官，其主要功能之一是提供针对潜在感染的保护。皮肤的水合作用与正常功能有关，它可以防止伤口或裂缝的出现，这些伤口或裂缝可能导致感染或其他皮肤病的改变。由于脚部承受的负荷，其皮肤比身体其他部位的皮肤更厚，而且更难保持。本研究的目的是评估与安慰剂霜相比，不同浓度（5％和 20％）的尿素对脚部保湿的效果。
该研究纳入了 60 名年龄在 20 至 35 岁之间的受试者。通过创建三个随机组（1:1:1）来启动实验方案，每组分别用不同的乳膏进行治疗：安慰剂、5％尿素乳膏和 20％尿素乳膏。使用非侵入性仪器（Corneometer CM 825®）进行检查，该仪器可检测皮肤表面的水合作用。
根据所使用的乳膏分析不同研究区域的皮肤水合作用，在前 3 个月和足跟处，安慰剂与 5％尿素之间没有显著差异，但在第 5 个月时有显著差异。在所有研究区域，安慰剂与 20％尿素乳膏之间均存在显著差异，但 5％尿素与 20％尿素乳膏之间没有差异。
讨论/结论：与安慰剂相比，20％尿素乳膏可使皮肤水合作用增加，但比较 20％和 5％尿素乳膏、安慰剂和 5％尿素乳膏时，均未发现差异。
