丙型肝炎病毒感染相关糖尿病的分子机制。
Molecular mechanisms underlying hepatitis C virus infection-related diabetes.
机构信息
National Clinical Research Center for Metabolic Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, 410011, Hunan, China; Key Laboratory of Diabetes Immunology, Ministry of Education, and Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, 139 Middle Renmin Road, Changsha, 410011, Hunan, China.
Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410011, Hunan, China.
出版信息
Metabolism. 2021 Aug;121:154802. doi: 10.1016/j.metabol.2021.154802. Epub 2021 Jun 3.
Diabetes is a noncommunicable widespread disease that poses the risk of severe complications in patients, with certain complications being life-threatening. Hepatitis C is an infectious disease that mainly causes liver damage, which is also a profound threat to human health. Hepatitis C virus (HCV) infection has many extrahepatic manifestations, including diabetes. Multiple mechanisms facilitate the strong association between HCV and diabetes. HCV infection can affect the insulin signaling pathway in liver and pancreatic tissue and change the profiles of circulating microRNAs, which may further influence the occurrence and development of diabetes. This review describes how HCV infection causes diabetes and discusses the current research progress with respect to HCV infection-related diabetes.
糖尿病是一种非传染性的广泛疾病，会使患者面临严重并发症的风险，某些并发症可能危及生命。丙型肝炎是一种传染病，主要导致肝脏损伤，也对人类健康构成严重威胁。丙型肝炎病毒（HCV）感染有许多肝外表现，包括糖尿病。多种机制促进了 HCV 与糖尿病之间的强关联。HCV 感染可影响肝和胰腺组织中的胰岛素信号通路，并改变循环 microRNA 的谱，这可能进一步影响糖尿病的发生和发展。本综述描述了 HCV 感染如何导致糖尿病，并讨论了目前关于 HCV 感染相关糖尿病的研究进展。
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