硅尘暴露增加类风湿关节炎发病风险：一项瑞典全国登记处病例对照研究。
Silica Dust Exposure Increases Risk for Rheumatoid Arthritis: A Swedish National Registry Case-Control Study.
机构信息
Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Sweden (Mr Wrangel, Bryngelsson, Dr Fornander, and Dr Vihlborg); National Institute of Occupational Health (STAMI), Oslo, Norway (Dr Graff); Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (Dr Wiebert); Centre for Occupational and Environmental Medicine, Region Stockholm, Sweden (Dr Wiebert); Department of Geriatrics, Faculty of Medicine and Health, Örebro University, Sweden (Dr Vihlborg).
出版信息
J Occup Environ Med. 2021 Nov 1;63(11):951-955. doi: 10.1097/JOM.0000000000002281.
OBJECTIVE
Rheumatoid arthritis (RA) is an inflammatory disease with unknown etiology. This study examines if silica dust exposure increases the risk for seropositive and seronegative RA.
METHODS
A nationwide registry case-control study was conducted that included all cases of RA in Sweden between 2005 and 2016. In total, 31,139 cases with two matched controls were included. A JEM was used to estimate exposure.
RESULTS
Silica dust exposure was associated with a statistically significant increase in odds ratio (OR) for seropositive (OR 1.22, 95% CI 1.05 to 1.40) and seronegative (OR 1.23, 95% CI 1.04 to 1.46) RA among men.
CONCLUSION
This study found an increased OR for RA in silica-exposed men. The OR was equal for seropositive and seronegative RA. These findings further support the hypothesis that silica dust may be a trigger for RA.
目的
类风湿关节炎（RA）是一种病因不明的炎症性疾病。本研究旨在探讨二氧化硅粉尘暴露是否会增加血清阳性和血清阴性 RA 的发病风险。
方法
开展了一项全国范围内的基于登记的病例对照研究，纳入了瑞典 2005 年至 2016 年间所有的 RA 病例。共纳入了 31139 例病例和 62278 例对照。采用 JEM 评估暴露情况。
结果
在男性中，二氧化硅粉尘暴露与血清阳性（OR 1.22，95%CI 1.05 至 1.40）和血清阴性（OR 1.23，95%CI 1.04 至 1.46）RA 的比值比（OR）显著增加相关。
结论
本研究发现，二氧化硅暴露的男性患 RA 的 OR 增加。血清阳性和血清阴性 RA 的 OR 相等。这些发现进一步支持了二氧化硅粉尘可能是 RA 发病的一个诱因的假说。
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