Alizadeh Mohammad, Karandish Majid, Asghari Jafarabadi Mohammad, Heidari Lida, Nikbakht Roshan, Babaahmadi Rezaei Hossein, Mousavi Reihaneh
Department of Clinical Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Science, Tabriz, Iran.
Nutrition and Metabolic Disease Research Center, Clinical Science Research Institute, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
Nutr Metab (Lond). 2021 Jun 6;18(1):57. doi: 10.1186/s12986-021-00586-9.
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. This study was designed to investigate the effects of melatonin and/or magnesium supplementation on metabolic profile and levels of sex hormones in PCOS women.
In an 8-week randomized double-blind placebo-controlled trial, 84 subjects with PCOS aged 18-40 years were randomly assigned based on the random block procedure to take magnesium, melatonin, magnesium plus melatonin, and placebo. Fasting blood samples were obtained at the beginning and end of the study.
After intervention, the mean Pittsburg Sleep Quality Index score decreased significantly in both co-supplementation and melatonin groups (P < 0.001). Magnesium supplementation in combination with melatonin resulted in a significant greater decrease in testosterone concentrations compared with the placebo (P < 0.05). Co-supplementation of magnesium-melatonin had significantly reduced serum insulin levels (geometric means difference: - 1.11 (mIU/mL) (percent change: - 15.99)), homeostasis model of assessment-insulin resistance (HOMA-IR) (- 0.28 (- 18.66)), serum cholesterol (mean difference: - 16.08 (mg/dl) [95% CI - 24.24, - 7.92]), low-density lipoprotein cholesterol (LDL-C) - 18.96 (mg/dl) [- 28.73, - 9.20]) and testosterone levels (- 0.09 (ng/ml) (- 25.00)), as compared to the baseline values (P < 0.05). An increase in serum high-density lipoprotein cholesterol (HDL-C) levels was also observed following the administration of the melatonin alone (2.76 (mg/dl) [0.57, 4.95]) or in combination with magnesium (2.19 (mg/dl) [0.61, 3.77]) (P < 0.05).
Co-supplementation with magnesium and melatonin had beneficial effects on sleep quality and total testosterone. Additionally, melatonin supplementation alone was found to be associated with a significant reduction in PSQI score. Moreover, combined melatonin and magnesium supplementation was more effective in improving serum levels of cholesterol, LDL-C, HDL-C and insulin, and HOMA-IR.
Iranian Registry of Clinical Trial. http://www.irct.ir : IRCT20191130045556N1, January 2020.
多囊卵巢综合征（PCOS）是育龄女性中最常见的内分泌疾病之一。本研究旨在探讨补充褪黑素和/或镁对PCOS女性代谢谱和性激素水平的影响。
在一项为期8周的随机双盲安慰剂对照试验中，84名年龄在18 - 40岁的PCOS受试者根据随机区组程序被随机分配服用镁、褪黑素、镁加褪黑素和安慰剂。在研究开始和结束时采集空腹血样。
干预后，联合补充组和褪黑素组的匹兹堡睡眠质量指数平均得分均显著降低（P < 0.001）。与安慰剂相比，镁与褪黑素联合补充导致睾酮浓度显著降低（P < 0.05）。镁 - 褪黑素联合补充显著降低了血清胰岛素水平（几何均数差值：-1.11（mIU/mL）（百分比变化：-15.99））、稳态模型评估 - 胰岛素抵抗（HOMA - IR）（-0.28（-18.66））、血清胆固醇（平均差值：-16.08（mg/dl）[95%CI -24.24，-7.92]）、低密度脂蛋白胆固醇（LDL - C）-18.96（mg/dl）[-28.73，-9.20]）和睾酮水平（-0.09（ng/ml）（-25.00）），与基线值相比（P < 0.05）。单独服用褪黑素（2.76（mg/dl）[0.57，4.95]）或与镁联合服用（2.19（mg/dl）[0.61，3.77]）后，血清高密度脂蛋白胆固醇（HDL - C）水平也有所升高（P < 0.05）。
镁和褪黑素联合补充对睡眠质量和总睾酮有有益影响。此外，单独补充褪黑素与PSQI评分显著降低有关。此外，褪黑素和镁联合补充在改善血清胆固醇、LDL - C、HDL - C和胰岛素水平以及HOMA - IR方面更有效。
伊朗临床试验注册中心。http://www.irct.ir ：IRCT2019年11月30日045556N1，2020年1月。
