Tateishi Kensuke
Department of Neurosurgery, Yokohama City University School of Medicine.
No Shinkei Geka. 2021 May;49(3):476-484. doi: 10.11477/mf.1436204419.
In this review, I summarized the biology of gliomas. Through past clinical and basic studies, I reviewed the evidence of the cell of origin of gliomas and the presence of brain tumor-initiating cells in gliomas, which are driven by multiple genomic alterations. In addition, the complicated tumor heterogeneity and neuronal-glioma network were studied. These mechanisms may underlie the treatment resistance and poor prognosis and support the identification of novel therapeutic targets for gliomas.
在本综述中，我总结了胶质瘤的生物学特性。通过过去的临床和基础研究，我回顾了胶质瘤起源细胞的证据以及胶质瘤中脑肿瘤起始细胞的存在情况，这些均由多种基因组改变所驱动。此外，还研究了复杂的肿瘤异质性和神经元-胶质瘤网络。这些机制可能是治疗抵抗和预后不良的基础，并支持确定胶质瘤的新型治疗靶点。
