Maqsood Sundas, Elsawah Kareem, Dhillon Navpreet, Soliman Shady, Laginaf Masara, Lodhia Vaishali, Lake Damian, Hamada Samer, Elalfy Mohamed
Corneo-Plastic Unit, Queen Victoria Hospital NHS, East Grinstead, UK.
Eye Department, Maidstone and Turnbridge Wells Hospitals, Maidstone, UK.
Clin Ophthalmol. 2021 May 28;15:2231-2238. doi: 10.2147/OPTH.S299141. eCollection 2021.
To report the outcomes of using human amniotic membrane-derived dry matrix (AMDDM) in the management of persistent corneal epithelial defects (PEDs) of various etiologies.
A cohort study of 84 patients age range 7 to 92 years with 93 PEDs were treated with AMDDM (Omnigen using OmniLenz at two centers (Queen Victoria Hospital and Maidstone Hospital) in the UK. The main outcome measures were healing response of PED and time to heal after application of AMDDM.
A total of 106 applications of AMDDM were recorded for 81 patients (52 males, 29 females) with a spectrum of different etiologies. Fifty-eight percent of the eyes showed complete healing, and 28% showed partial decrease of the size of PEDs with average treatment length recorded as 22.4±12.3 days. In patients with limbal stem cell deficiency (n=44; aniridia=12, chemical injury=9, Stevens-Johnson syndrome=10), 50% of PEDs showed complete healing and 27% showed partial healing. In patients with microbial keratitis (n=21) (bacterial: 13, fungal: 4, herpetic: 3, : 1) 57% of PEDs showed complete healing and 33% were partially healed. In patients with keratoplasty (n=16), 56% of PEDs showed complete healing and 31% were partially healed. Vision remained stable in 59% and improved in 27% of the study the population.
AMDDM can be easily applied in the clinical setting and has demonstrated its efficiency as a new tool to treat persistent epithelial defects.
报告使用人羊膜源干基质（AMDDM）治疗各种病因所致持续性角膜上皮缺损（PED）的效果。
对英国两家中心（维多利亚女王医院和梅德斯通医院）84例年龄在7至92岁、患有93处PED的患者进行队列研究，采用AMDDM（Omnigen搭配OmniLenz）治疗。主要观察指标为PED的愈合反应及应用AMDDM后的愈合时间。
共记录了81例患者（52例男性，29例女性）的106次AMDDM应用情况，病因各异。58%的患眼实现完全愈合，28%的患眼PED面积部分缩小，平均治疗时长记录为22.4±12.3天。在角膜缘干细胞缺乏患者（n = 44；无虹膜症 = 12例，化学伤 = 9例，史蒂文斯 - 约翰逊综合征 = 10例）中，50%的PED完全愈合，27%部分愈合。在微生物性角膜炎患者（n = 21）（细菌性：13例，真菌性：4例，疱疹性：3例，其他：1例）中，57%的PED完全愈合，33%部分愈合。在角膜移植患者（n = 16）中，56%的PED完全愈合，31%部分愈合。59%的研究人群视力保持稳定，27%视力改善。
AMDDM可轻松应用于临床，已证明其作为治疗持续性上皮缺损的新工具的有效性。
