Sun Xinzhu, Liu Dongyan, Ge Nan, Guo Jintao, Wang Sheng, Liu Xiang, Wang Guoxin, Sun Siyu
Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
Department of Gastroenterology and Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
Cancer Manag Res. 2021 May 28;13:4251-4262. doi: 10.2147/CMAR.S308809. eCollection 2021.
There are few biomarkers available for the early diagnosis and prognostic evaluation of pancreatic cancer. In addition, the development of targeted therapy for pancreatic cancer is an unmet need due to the lack of molecular targets. With the continuous progress in circular RNA (circRNA)-related research, its role in the occurrence and development of pancreatic cancer has been discovered and gradually recognized. Therefore, circRNA may represent a novel marker for early diagnosis of this disease and a focus of targeted clinical therapy. CircRNA is a type of non-coding RNA with a closed circular structure formed by covalent bonds. Some circRNAs can act as "sponges" to adsorb microRNAs (miRNAs) and play the role of competitive endogenous RNA (ceRNA) to remove their inhibitory effects on the target genes of miRNA. Thus, they can indirectly restore the expression of target genes. The circRNA-miRNA-mRNA network plays a regulatory role in the proliferation, invasion, metastasis, and other biological behaviors of pancreatic cancer. Given the recent advances in circRNA, this review seeks to provide an overview of the biological function of circRNA and highlights the recent research progress regarding the molecular mechanism of circRNA for the clinical diagnosis and treatment of pancreatic cancer.
目前可用于胰腺癌早期诊断和预后评估的生物标志物很少。此外，由于缺乏分子靶点，胰腺癌靶向治疗的发展仍是未满足的需求。随着环状RNA（circRNA）相关研究的不断进展，其在胰腺癌发生发展中的作用已被发现并逐渐得到认可。因此，circRNA可能代表这种疾病早期诊断的新型标志物以及靶向临床治疗的重点。CircRNA是一种具有由共价键形成的封闭环状结构的非编码RNA。一些circRNA可以充当“海绵”吸附微小RNA（miRNA），并发挥竞争性内源RNA（ceRNA）的作用，消除它们对miRNA靶基因的抑制作用。因此，它们可以间接恢复靶基因的表达。CircRNA-miRNA-mRNA网络在胰腺癌的增殖、侵袭、转移及其他生物学行为中发挥调节作用。鉴于circRNA的最新进展，本综述旨在概述circRNA的生物学功能，并突出circRNA在胰腺癌临床诊断和治疗分子机制方面的最新研究进展。
