阿米卡星增强顺二氨二氯铂对大鼠的肾毒性
Potentiation of cis-diamminedichloroplatinum nephrotoxicity by amikacin in rats.
作者信息
Jongejan H T, Provoost A P, Molenaar J C
机构信息
Department of Pediatric Surgery, Erasmus University, Rotterdam, The Netherlands.
出版信息
Cancer Chemother Pharmacol. 1988;22(2):178-80. doi: 10.1007/BF00257319.
The nephrotoxic interaction between cis-diamminedichloroplatinum (CDDP) and amikacin (AMI) was studied in rats. Following a single dose of CDDP (5 mg/kg i.v.), AMI (60 mg/kg s.c.) was given for 14 days. When given alone CDDP caused a 40% fall in the glomerular filtration rate (GFR), whereas AMI alone had no effect on GFR. This nonnephrotoxic course of AMI potentiated the CDDP-induced fall in GFR. Only a limited recovery of renal function was observed during a 15-week follow-up period.
在大鼠中研究了顺二氯二氨铂（CDDP）与阿米卡星（AMI）之间的肾毒性相互作用。单次静脉注射CDDP（5 mg/kg）后，皮下注射AMI（60 mg/kg），持续14天。单独给予CDDP时，肾小球滤过率（GFR）下降40%，而单独给予AMI对GFR无影响。AMI的这种无肾毒性过程增强了CDDP诱导的GFR下降。在15周的随访期内，仅观察到有限的肾功能恢复。
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