顺二氨二氯铂（CDDP）对肾功能的急性影响。
Acute effects of cis-diamminedichloroplatinum (CDDP) on renal function.
作者信息
Offerman J J, Meijer S, Sleijfer D T, Mulder N H, Donker A J, Koops H S, van der Hem G K
出版信息
Cancer Chemother Pharmacol. 1984;12(1):36-8. doi: 10.1007/BF00255906.
PMID:6537801
Abstract
Ten previously untreated patients with metastatic non-seminomatous testicular carcinoma received cis-diamminedichloroplatinum (CDDP). Renal function studies were performed before and following the first CDDP infusion. A decrease in effective renal plasma flow (ERPF) and an increase in filtration fraction (FF) was found in all patients. These findings suggest primary changes in renal hemodynamics during CDDP infusion.
摘要
十名先前未经治疗的转移性非精原细胞瘤性睾丸癌患者接受了顺二氯二氨铂（CDDP）治疗。在首次输注CDDP之前和之后进行了肾功能研究。发现所有患者的有效肾血浆流量（ERPF）均下降，滤过分数（FF）均升高。这些发现提示在输注CDDP期间肾脏血流动力学发生了原发性变化。
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