Xu Chunfeng, Wang Mingjie, Guo Wei, Sun Wei, Liu Yuelian
Section of Restorative and Reconstructive Oral Care, Department of Oral Health Sciences, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Department of Oral-Maxillofacial and Head-Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Front Oncol. 2021 May 20;11:672490. doi: 10.3389/fonc.2021.672490. eCollection 2021.
Osteosarcoma is a dominating malignant bone tumor with high mortality due to pulmonary metastases. Furthermore, because of the cancer cell erosion and surgery resection, osteosarcoma always causes bone defects, which means dysfunction and disfigurement are seldom inevitable. Although various advanced treatments (e.g. chemotherapy, immunotherapy, radiotherapy) are coming up, the 5-year survival rate for osteosarcoma with metastases is still dismal. In line with this, the more potent treatments for osteosarcoma are in high demand. Curcumin, a perennial herb, has been reportedly applied in the therapy of various types of tumors via different mechanisms. , it has also been reported that curcumin can inhibit the proliferation of osteosarcoma cell lines and can be used to repair bone defects. This seems curcumin is a promising candidate in osteosarcoma treatment. However, due to its congenital property like hydrophobicity, and low bioavailability, affecting its anticancer effect, clinical applications of curcumin are highly limited. To enhance its performance in cancer therapies, some synergist approaches with curcumin have emerged. The present review presents some prospective ones (i.e. combinations with immunotherapy, chemotherapeutics, bone tissue engineering, and biomaterials) applied in osteosarcoma treatment. Additionally, with the advancements of photodynamic therapy in cancer therapy, this review also prospects the combination of curcumin with photodynamic therapy in osteosarcoma treatment.
骨肉瘤是一种主要的恶性骨肿瘤，因肺转移导致死亡率很高。此外，由于癌细胞侵蚀和手术切除，骨肉瘤总会导致骨缺损，这意味着功能障碍和外形损毁几乎不可避免。尽管各种先进治疗方法（如化疗、免疫疗法、放疗）不断涌现，但伴有转移的骨肉瘤的5年生存率仍然很低。与此相符的是，对骨肉瘤更有效的治疗方法需求迫切。姜黄素是一种多年生草本植物，据报道已通过不同机制应用于各类肿瘤的治疗。此外，也有报道称姜黄素可抑制骨肉瘤细胞系的增殖，并可用于修复骨缺损。这似乎表明姜黄素是骨肉瘤治疗中一个有前景的候选药物。然而，由于其固有的疏水性等特性以及低生物利用度，影响了其抗癌效果，姜黄素的临床应用受到极大限制。为提高其在癌症治疗中的性能，一些与姜黄素的协同方法已出现。本综述介绍了一些应用于骨肉瘤治疗的前瞻性方法（即与免疫疗法、化疗药物、骨组织工程和生物材料的联合应用）。此外，随着光动力疗法在癌症治疗中的进展，本综述还展望了姜黄素与光动力疗法联合应用于骨肉瘤治疗的前景。
