利妥昔单抗联合环磷酰胺、阿霉素、长春新碱及泼尼松化疗治疗抗干扰素-γ自身抗体所致播散性复杂疾病：一例报告
R-CHOP Chemotherapy for Disseminated Complex Disease due to Anti-Interferon-Gamma Autoantibodies: A Case Report.
作者信息
Uno Shunsuke, Uehara Eisuke, Kimura Toshiki, Sakagami Takuro, Namkoong Ho, Uchida Sho, Uwamino Yoshifumi, Hasegawa Naoki
机构信息
Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Department of Hematology, Sainokuni Higashiomiya Medical Center, Saitama, Japan.
出版信息
Open Forum Infect Dis. 2021 Apr 10;8(6):ofab181. doi: 10.1093/ofid/ofab181. eCollection 2021 Jun.
A 77-year-old Japanese man with disseminated complex (MAC) disease due to anti-interferon-gamma autoantibodies received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy because of non-Hodgkin lymphoma complication. The hepatobiliary nodules due to MAC resolved with R-CHOP and multidrug antimycobacterial treatment. R-CHOP could serve as an alternative adjunctive therapy for patients with anti-interferon-gamma autoantibodies.
一名77岁的日本男性因抗干扰素-γ自身抗体导致播散性鸟分枝杆菌复合体（MAC）病，因非霍奇金淋巴瘤并发症接受了利妥昔单抗、环磷酰胺、阿霉素、长春新碱和泼尼松龙（R-CHOP）化疗。由MAC引起的肝胆结节通过R-CHOP和多药抗分枝杆菌治疗得以消退。R-CHOP可作为抗干扰素-γ自身抗体患者的一种替代辅助治疗方法。
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