反应中三苯基氧化膦的去除：溶剂和温度的作用。
Triphenylphosphine Oxide Removal from Reactions: The Role of Solvent and Temperature.
作者信息
Tamboli Yasinalli, Kashid Bharat B, Yadav Ram Prasad, Rafeeq Mohammad, Yeole Ravindra, Merwade Arvind Y
机构信息
Chemical Research, Wockhardt Research Centre, D-4, MIDC, Chikalthana, Aurangabad 431 006, India.
Department of Analytical Chemistry, Wockhardt Research Centre, D-4, MIDC, Chikalthana, Aurangabad 431 006, India.
出版信息
ACS Omega. 2021 May 19;6(21):13940-13945. doi: 10.1021/acsomega.1c01996. eCollection 2021 Jun 1.
Here, a large-scale feasible, chromatography-free process to purge triphenylphosphine oxide (TPPO) from the crude product of Mitsunobu and Wittig reactions has been developed. Divergence in physicochemical properties like polarity and solubility of TPPO against the product was utilized to precipitate TPPO directly from the reaction mixture and eliminate by simple filtration on a kilogram scale at a pilot plant with high purity of the product.
在此，已开发出一种大规模可行的、无需色谱法的工艺，用于从 Mitsunobu 反应和 Wittig 反应的粗产物中去除三苯基氧化膦（TPPO）。利用 TPPO 与产物在极性和溶解度等物理化学性质上的差异，直接从反应混合物中沉淀出 TPPO，并在中试工厂以千克规模通过简单过滤进行去除，同时获得高纯度的产物。
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