一种方便、温和的无需色谱分离即可纯化 Wittig 和 Appel 反应产物的方法。
A convenient and mild chromatography-free method for the purification of the products of Wittig and Appel reactions.
机构信息
Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
出版信息
Org Biomol Chem. 2012 May 7;10(17):3531-7. doi: 10.1039/c2ob07074j. Epub 2012 Mar 22.
PMID:22437367
Abstract
A mild method for the facile removal of phosphine oxide from the crude products of Wittig and Appel reactions is described. Work-up with oxalyl chloride to generate insoluble chlorophosphonium salt (CPS) yields phosphorus-free products for a wide variety of these reactions. The CPS product can be further converted into phosphine.
摘要
描述了一种从维蒂希和阿佩尔反应的粗产物中轻易去除氧化膦的温和方法。用草酰氯进行后处理以生成不溶性氯代磷翁盐（CPS），可得到各种此类反应的无磷产物。CPS 产物可进一步转化为磷烷。
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