使用高负载量的 Merrifield 树脂高效清除三苯基膦和三苯基氧膦。

Efficient scavenging of Ph3P and Ph3P=O with high-loading merrifield resin.

作者信息

Lipshutz B H, Blomgren P A

机构信息

Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA.

出版信息

Org Lett. 2001 Jun 14;3(12):1869-71. doi: 10.1021/ol0159219.

DOI:10.1021/ol0159219

PMID:11405732

Abstract

[see reaction]. A simple, highly effective method for removing triphenylphosphine and/or triphenylphosphine oxide from reaction mixtures is described. Commercially available high-loading chloromethylated polystyrene 1, modified in situ with NaI, acts as a scavenger resin. Several coupling reactions catalyzed by Pd(0) or Ni(0) which require the removal of triphenylphosphine are tested.

摘要

[见反应]。描述了一种从反应混合物中去除三苯基膦和/或三苯基氧化膦的简单、高效方法。市售的高负载氯甲基化聚苯乙烯1，用碘化钠原位改性，用作清除树脂。测试了几种由钯(0)或镍(0)催化且需要去除三苯基膦的偶联反应。