Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.
Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Cell Rep Med. 2021 Apr 29;2(5):100260. doi: 10.1016/j.xcrm.2021.100260. eCollection 2021 May 18.
Microbiota maturation and immune development occur in parallel with, and are implicated in, allergic diseases, and research has begun to demonstrate the importance of prenatal influencers on both. Here, we investigate the meconium metabolome, a critical link between prenatal exposures and both early microbiota and immune development, to identify components of the neonatal gut niche that contribute to allergic sensitization. Our analysis reveals that newborns who develop immunoglobulin E (IgE)-mediated allergic sensitization (atopy) by 1 year of age have a less-diverse gut metabolome at birth, and specific metabolic clusters are associated with both protection against atopy and the abundance of key taxa driving microbiota maturation. These metabolic signatures, when coupled with early-life microbiota and clinical factors, increase our ability to accurately predict whether or not infants will develop atopy. Thus, the trajectory of both microbiota colonization and immune development are significantly affected by metabolites present in the neonatal gut at birth.
微生物组成熟和免疫发育与过敏疾病平行发生，并与之相关，研究已经开始证明产前因素对两者都很重要。在这里，我们研究胎粪代谢组，这是产前暴露与早期微生物组和免疫发育之间的关键联系，以确定新生儿肠道生态位中导致过敏致敏的成分。我们的分析表明，在 1 岁时发生免疫球蛋白 E（IgE）介导的过敏致敏（特应性）的新生儿在出生时具有较少多样性的肠道代谢组，并且特定的代谢群集与特应性的保护和驱动微生物组成熟的关键分类群的丰度都有关。这些代谢特征，与早期生命的微生物群和临床因素相结合，提高了我们准确预测婴儿是否会发生特应性的能力。因此，微生物定植和免疫发育的轨迹都受到出生时新生儿肠道中存在的代谢物的显著影响。
