Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Buenos Aires, Argentina.
Unidad de Parasitología, Sector Micología, Hospital J. M. Ramos Mejía, Buenos Aires, Argentina.
Crit Rev Microbiol. 2021 Nov;47(6):762-780. doi: 10.1080/1040841X.2021.1927978. Epub 2021 Jun 7.
Fungal infections have increased in recent years due to host factors, such as oncohaematological and transplant-related disorders, immunosuppressive therapy, and AIDS. Additionally, molecular and proteomic facilities have become available to identify previously unrecognizable opportunists. For these reasons, reports on less-known and recalcitrant mycoses, such as those caused by black fungi, hyaline filamentous fungi, coelomycetes, Mucorales, and non- yeasts have emerged. In this review, novel taxonomy in these groups, which often are multi-resistant to one or several classes of antifungals, is discussed. Clinical presentations, diagnosis and current treatment of some major groups are summarised.
近年来，由于宿主因素，如恶性血液病和移植相关疾病、免疫抑制治疗和艾滋病，真菌感染有所增加。此外，还出现了分子和蛋白质组学设施，以识别以前无法识别的机会主义者。由于这些原因，出现了关于较少见和难治性真菌感染的报告，如黑真菌、透明丝状真菌、腔孢菌、毛霉目和非酵母引起的真菌感染。在这篇综述中，讨论了这些通常对一种或几种类别的抗真菌药物具有多药耐药性的群体中的新分类。总结了一些主要群体的临床表现、诊断和当前治疗方法。
