Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Int J Radiat Biol. 2021;97(9):1282-1288. doi: 10.1080/09553002.2021.1931527. Epub 2021 Jun 7.
Evaluation of the organ dose in pediatric patients up to 15 years old and Estimation of lifetime attributable risk (LAR) of cancer incidence in pediatric computed tomography procedures.
Data from 532 patients below 15 years old was collected and they were categorized into four age groups of <1, 1-5, 5-10, and 10-15 years old. NCICT software was used to calculate the organ dose, and LAR of cancer incidence has been estimated according to the BEIR VII report.
The highest median dose in all age groups was related to eye lens (head scan), thyroid (chest scan), and colon (abdomen-pelvic scan). The highest average LAR of cancer incidence was observed for breast cancer and colon cancer following a chest CT scan of the youngest group (<1-year-olds) [68.23 per 100,000] and abdomen-pelvic scans of the oldest group (10- to 15-year-olds) [57.30 per 100,000].
This study shows that the average LAR is higher in females and it decreases with age in both genders. Although CT scan has an indispensable application in diagnosis, the patient dose should be taken into account before any examination specifically in pediatric patients.
评估 15 岁以下儿科患者的器官剂量，并估算儿科计算机断层扫描（CT）检查中癌症发病的终生归因风险（LAR）。
收集了 532 名 15 岁以下患者的数据，并将其分为<1 岁、1-5 岁、5-10 岁和 10-15 岁四个年龄组。使用 NCICT 软件计算器官剂量，并根据 BEIR VII 报告估算癌症发病的 LAR。
所有年龄组中，最高的中位数剂量与眼部晶状体（头部扫描）、甲状腺（胸部扫描）和结肠（腹部-盆腔扫描）有关。在胸部 CT 扫描中，年龄最小的组（<1 岁）中乳腺癌和结肠癌的 LAR 最高（68.23/10 万），而在腹部-盆腔扫描中，年龄最大的组（10-15 岁）中结肠癌的 LAR 最高（57.30/10 万）。
本研究表明，女性的平均 LAR 较高，且在两性中均随年龄增长而降低。尽管 CT 扫描在诊断中具有不可或缺的应用，但在进行任何检查前，特别是在儿科患者中，应考虑患者剂量。
