Franck Caro, Vandevoorde Charlot, Goethals Ingeborg, Smeets Peter, Achten Eric, Verstraete Koenraad, Thierens Hubert, Bacher Klaus
Department of Basic Medical Sciences, Ghent University, Proeftuinstraat 86, 9000, Ghent, Belgium.
Nuclear Medicine Department, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.
Eur Radiol. 2016 Aug;26(8):2646-55. doi: 10.1007/s00330-015-4091-7. Epub 2015 Dec 15.
To develop a clinically applicable method to estimate patient-specific organ and blood doses and lifetime attributable risks (LAR) from paediatric torso CT examinations.
Individualized voxel models were created from full-body CT data of 10 paediatric patients (2-18 years). Patient-specific dose distributions of chest and abdominopelvic CT scans were simulated using Monte Carlo methods. Blood dose was calculated as a weighted sum of simulated organ doses. LAR of cancer incidence and mortality were estimated, according to BEIR-VII. A second simulation and blood dose calculation was performed using only the thoracic and abdominopelvic region of the original voxel models. For each simulation, the size-specific dose estimate (SSDE) was calculated.
SSDE showed a significant strong linear correlation with organ dose (r > 0.8) and blood dose (r > 0.9) and LAR (r > 0.9). No significant differences were found between blood dose calculations with the full-body voxel models and the thoracic or abdominopelvic models.
Even though clinical CT images mostly do not cover the whole body of the patient, they can be used as a voxel model for blood dose calculation. In addition, SSDE can estimate patient-specific organ and blood doses and LAR in paediatric torso CT examinations.
• Blood dose can be simulated using the patient's clinical CT images. • SSDE estimates patient-specific organ/blood dose and LAR in paediatric CAP CT-examinations. • SSDE makes on-the-spot dose and LAR estimations possible in routine clinical practice.
开发一种临床适用的方法，用于估算儿科躯干CT检查中患者特定的器官和血液剂量以及终生归因风险（LAR）。
根据10名儿科患者（2 - 18岁）的全身CT数据创建个体化体素模型。使用蒙特卡罗方法模拟胸部和腹部盆腔CT扫描的患者特定剂量分布。血液剂量计算为模拟器官剂量的加权总和。根据BEIR - VII估算癌症发病率和死亡率的LAR。仅使用原始体素模型的胸部和腹部盆腔区域进行第二次模拟和血液剂量计算。对于每次模拟，计算尺寸特异性剂量估计值（SSDE）。
SSDE与器官剂量（r > 0.8）、血液剂量（r > 0.9）和LAR（r > 0.9）显示出显著的强线性相关性。全身体素模型与胸部或腹部盆腔模型的血液剂量计算之间未发现显著差异。
尽管临床CT图像大多未覆盖患者的全身，但它们可作为血液剂量计算的体素模型。此外，SSDE可估算儿科躯干CT检查中患者特定的器官和血液剂量以及LAR。
• 可使用患者的临床CT图像模拟血液剂量。• SSDE可估算儿科胸部和腹部盆腔CT检查中患者特定的器官/血液剂量和LAR。• SSDE使常规临床实践中的现场剂量和LAR估算成为可能。
